uu.seUppsala University Publications
Change search
ReferencesLink to record
Permanent link

Direct link
Effect of inhibition of pentagastrin-stimulated acid secretion on gastric mucosal gland luminal pressure.
1997 (English)In: Acta Physiologica Scandinavica, ISSN 0001-6772, E-ISSN 1365-201X, Vol. 160, no 1, 103-11 p.Article in journal (Refereed) Published
Abstract [en]

We demonstrated previously that hydrochloric acid secreted from the gastric glands traverses the mucus layer in channels above the gland openings. The driving force for creation of these channels is most probably the hydrostatic pressure generated in the gastric gland lumen during stimulation of acid secretion. Here we investigated the effect of total inhibition of acid secretion on gland luminal pressure. Glandular pressure was measured in vivo with a pressure-sensitive microelectrode technique in Inactin-anaesthetized Sprague Dawley or Lewis x DA F1 rats. Glandular pressure was significantly reduced after ranitidine inhibition of acid secretion, from 17.2 +/- 2.1 mmHg during pentagastrin stimulation to 11.2 +/- 1.2 mmHg. This was also true when pentagastrin infusion was continued after inhibition of secretion with ranitidine. Omeprazole, however, did not significantly alter gland luminal pressure although it totally inhibited acid secretion. With continuation of pentagastrin infusion after omeprazole inhibition, glandular pressure increased significantly from 17.6 +/- 3.4 to 20.1 +/- 3.3 mmHg. In conclusion, total inhibition of acid secretion with ranitidine reduces but does not abolish gland luminal pressure. After omeprazole inhibition of acid secretion the gastric gland luminal pressure persisted or even increased. Since the volume secretion is lower after omeprazole administration than during pentagastrin stimulation, the outflow resistance most probably had increased after omeprazole injection. Suggestions for increased outflow resistance are narrowing in the upper part of the gland lumen by conformational changes of the cells or muscle contractions, and/or an increase in mucus secretion or viscosity.

Place, publisher, year, edition, pages
1997. Vol. 160, no 1, 103-11 p.
National Category
URN: urn:nbn:se:uu:diva-188465PubMedID: 9179318OAI: oai:DiVA.org:uu-188465DiVA: diva2:577969
Available from: 2012-12-17 Created: 2012-12-17 Last updated: 2012-12-17

Open Access in DiVA

No full text


Search in DiVA

By author/editor
Holm, Lena
In the same journal
Acta Physiologica Scandinavica

Search outside of DiVA

GoogleGoogle Scholar

Altmetric score

Total: 267 hits
ReferencesLink to record
Permanent link

Direct link