uu.seUppsala University Publications
Change search
ReferencesLink to record
Permanent link

Direct link
Gastric mucosal smooth muscles may explain oscillations in glandular pressure: role of vasoactive intestinal peptide.
1998 (English)In: Gastroenterology, ISSN 0016-5085, Vol. 114, no 2, 284-94 p.Article in journal (Refereed) Published
Abstract [en]

BACKGROUND & AIMS: Oscillating (3-7 cycles/min) high pressures in gastric glands during acid secretion suggest the existence of rhythmically contracting mucosal muscles. The aim of this study was to study vasoactive intestinal peptide (VIP), an inhibitory neurotransmitter in the gastrointestinal tract, in relation to mucosal muscles, glandular pressure, and blood flow.

METHODS: Rat, dog, and human mucosae were examined immunocytochemically for smooth muscle actin and VIP. Glandular pressure was measured using microelectrodes, red blood cell velocity (V[RBC]) was measured using a cross-correlation technique, and blood flow was measured using laser Doppler flowmetry in exposed gastric mucosa of thiobutabarbital sodium-anesthetized rats.

RESULTS: Actin immunostaining showed muscle strands arising from muscularis mucosae, extending toward the gastric pits. VIP-immunoreactive nerve fibers were found in close relation to these muscles. VIP, administered intra-arterially close to the stomach (2 microg/kg bolus, followed by 10 microg x kg[-1] x h[-1]), significantly decreased glandular pressure from 18.2 +/- 1.6 to 8.9 +/- 1.6 mm Hg and almost eliminated the pressure oscillations. VIP infusion also abolished the oscillations in V(RBC) and significantly increased blood flow by approximately 35%.

CONCLUSIONS: Contracting mucosal muscles may be responsible for oscillations in glandular pressure and possibly also in V(RBC). VIP probably relaxes these muscles.

Place, publisher, year, edition, pages
1998. Vol. 114, no 2, 284-94 p.
National Category
URN: urn:nbn:se:uu:diva-188464PubMedID: 9453488OAI: oai:DiVA.org:uu-188464DiVA: diva2:577970
Available from: 2012-12-17 Created: 2012-12-17 Last updated: 2012-12-17

Open Access in DiVA

No full text


Search in DiVA

By author/editor
Holm, Lena
In the same journal

Search outside of DiVA

GoogleGoogle Scholar
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

Altmetric score

Total: 262 hits
ReferencesLink to record
Permanent link

Direct link