uu.seUppsala University Publications
Change search
ReferencesLink to record
Permanent link

Direct link
Prostaglandin E2 and aggressive factors increase the gland luminal pressure in the rat gastric mucosa in vivo.
1998 (English)In: Gastroenterology, ISSN 0016-5085, Vol. 114, no 6, 1276-86 p.Article in journal (Refereed) Published
Abstract [en]

BACKGROUND & AIMS: The gastroprotective properties of prostaglandins in low concentrations are still unclear. In this study, we investigated the effects of prostaglandin E2 (PGE2), indomethacin, and intraluminally applied HCl or ethanol on intraglandular pressure, mucus thickness, acid secretion, and gastric mucosal blood flow.

METHODS: Glandular pressure and mucous gel thickness were measured with microelectrodes during intravital microscopy in thiobutabarbital sodium-anesthetized rats. Gastric blood flow was measured with laser Doppler flowmetry.

RESULTS: In pentagastrin-treated rats, glandular pressure increased significantly in response to topical (1 micrograms/mL) or intra-arterial (12 micrograms.kg-1.h-1) PGE2 from approximately 17 to 69 and 18 to 57 mm Hg, respectively, whereas blood flow, mucus thickness, and acid secretion were unaltered. Indomethacin (3 mg/kg intravenously) significantly decreased glandular pressure from approximately 20 to 11 mm Hg. Intraluminal application of 10 and 100 mmol/L HCl or 20% and 40% ethanol significantly increased glandular pressure but had no effect after indomethacin pretreatment.

CONCLUSIONS: Endogenous PGE2 is important for maintaining a high glandular pressure, and exogenous PGE2 potently increases glandular pressure at concentrations not altering blood flow, mucus thickness, or acid secretion. This suggests that high intraglandular pressures might be involved in gastroprotection.

Place, publisher, year, edition, pages
1998. Vol. 114, no 6, 1276-86 p.
National Category
URN: urn:nbn:se:uu:diva-188463PubMedID: 9609765OAI: oai:DiVA.org:uu-188463DiVA: diva2:577971
Available from: 2012-12-17 Created: 2012-12-17 Last updated: 2012-12-17

Open Access in DiVA

No full text


Search in DiVA

By author/editor
Holm, Lena
In the same journal

Search outside of DiVA

GoogleGoogle Scholar
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

Altmetric score

Total: 278 hits
ReferencesLink to record
Permanent link

Direct link