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Prefrontal activity during response inhibition decreases over time in the postpartum period
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Women's and Children's Health. (Reproduktiv hälsa/Sundström Poromaa)
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Women's and Children's Health, Obstetrics and Gynaecology. Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Social Sciences, Department of Psychology. (Reproduktiv hälsa/Sundström Poromaa)
Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Social Sciences, Department of Psychology.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Radiology, Oncology and Radiation Science, Radiology.
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2013 (English)In: Behavioural Brain Research, ISSN 0166-4328, E-ISSN 1872-7549, Vol. 241, no 1, 132-138 p.Article in journal (Refereed) Published
Abstract [en]

The postpartum period is characterized by complex hormonal changes, but human imaging studies in the postpartum period have thus far predominantly focused on the neural correlates of maternal behavior or postpartum depression, whereas longitudinal studies on neural correlates of cognitive function across the postpartum period in healthy women are lacking. The aim of this study was to longitudinally examine response inhibition, as a measure of executive function, and its neural correlates in healthy postpartum women and non-postpartum controls. Thirteen healthy postpartum women underwent event-related functional magnetic resonance imaging while performing a Go/NoGo task. The first assessment was made within 48hours of delivery, and the second at 4-7 weeks postpartum. In addition, 13 healthy women examined twice during the menstrual cycle were included as non-postpartum controls. In postpartum women region of interest analyses revealed task-related decreased activations in the right inferior frontal gyrus, right anterior cingulate, and bilateral precentral gyri at the late postpartum assessment. Generally, postpartum women displayed lower activity during response inhibition in the bilateral inferior frontal gyri and precentral gyri compared to non-postpartum controls. No differences in response inhibition performance were found between time-points or between groups. In conclusion, this study has discovered that brain activity in prefrontal areas during a response inhibition task decreases throughout the course of the first postpartum weeks and is lower than in non-postpartum controls. Further studies on the normal adaptive brain activity changes that occur during the postpartum period are warranted.

Place, publisher, year, edition, pages
2013. Vol. 241, no 1, 132-138 p.
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Medical and Health Sciences
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URN: urn:nbn:se:uu:diva-188503DOI: 10.1016/j.bbr.2012.12.003ISI: 000315308700018PubMedID: 23238040OAI: oai:DiVA.org:uu-188503DiVA: diva2:577980
Available from: 2012-12-17 Created: 2012-12-17 Last updated: 2017-12-06Bibliographically approved

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Bannbers, ElinGingnell, MalinEngman, JonasMorell, ArvidSylvén, SaraSkalkidou, AlkistisKask, KristiinaWikström, JohanSundström Poromaa, Inger

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Bannbers, ElinGingnell, MalinEngman, JonasMorell, ArvidSylvén, SaraSkalkidou, AlkistisKask, KristiinaWikström, JohanSundström Poromaa, Inger
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Department of Women's and Children's HealthObstetrics and GynaecologyDepartment of PsychologyRadiology
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