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Effects of hypovolemia on blood flow, arterial [HCO3-], and HCO3- output in the rat duodenum.
1990 (English)In: American Journal of Physiology, ISSN 0002-9513, Vol. 259, no 2 Pt 1, G179-83 p.Article in journal (Refereed) Published
Abstract [en]

The effects of bleeding-induced hypovolemia on duodenal blood flow (microsphere technique), arterial [HCO3-], and duodenal HCO3- secretion (in situ titration) were investigated in chloralose-anesthetized rats. A 10% decrease in blood volume reduced duodenal HCO3- secretion by 44%, duodenal blood flow by 31%, and arterial [HCO3-] by 11%. In a group with cervically cut vagal nerves, basal duodenal HCO3- secretion was greater than 50% lower compared with controls. Basal blood flow and arterial [HCO3-] were on similar levels as in nonvagotomized animals. Furthermore, bleeding failed to lower duodenal alkaline output in rats with cut vagal nerves, although blood flow and arterial [HCO3-] were reduced to a similar extent as in the vagally intact controls. In a yohimbine-treated group, a 10% bleeding reduced duodenal blood flow by 28% and arterial [HCO3-] by 7% without influencing duodenal HCO3- secretion. We suggest that the hypovolemia-induced inhibition of duodenal alkaline secretion is not caused by a decrease in blood and/or arterial [HCO3-]. Instead, other factors may be of importance, for example, neural effects on enteric secretomotor neurons or directly on the secreting epithelium.

Place, publisher, year, edition, pages
1990. Vol. 259, no 2 Pt 1, G179-83 p.
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URN: urn:nbn:se:uu:diva-188633PubMedID: 2166439OAI: oai:DiVA.org:uu-188633DiVA: diva2:578449
Available from: 2012-12-18 Created: 2012-12-18 Last updated: 2012-12-18

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