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Voluntary ingestion of nut paste for administration of buprenorphine in rats and mice
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Neuroscience, Comparative Medicine.
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2012 (English)In: Laboratory Animals. Journal of the Laboratory Animal Science Association, ISSN 0023-6772, Vol. 46, no 4, 349-351 p.Article in journal (Refereed) Published
Abstract [en]

An adequate analgesic strategy is important to improve the postoperative recovery and welfare of laboratory rats and mice. It is desirable that the method for administering the drug is non-invasive and stress-free. We have previously validated a method for administering buprenorphine in a nut paste for voluntary ingestion. This method has many advantages over parenteral administration. To use the method in a successful way, however, it is important to prepare and administer the mix correctly. The present paper describes in detail how to implement the method, by means of habituation, presentation, adequate concentrations and amounts of buprenorphine/nut paste, and dosage of buprenorphine to rats and mice.

Place, publisher, year, edition, pages
2012. Vol. 46, no 4, 349-351 p.
Keyword [en]
Analgesia, voluntary ingestion, buprenorphine, rats, mice
National Category
Medical and Health Sciences
URN: urn:nbn:se:uu:diva-188567DOI: 10.1258/la.2012.012028ISI: 000311193000014OAI: oai:DiVA.org:uu-188567DiVA: diva2:578527
Available from: 2012-12-18 Created: 2012-12-17 Last updated: 2012-12-18Bibliographically approved

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Sundbom, Renée
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Comparative Medicine
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