A Genome-Wide Association Study of Monozygotic Twin-Pairs Suggests a Locus Related to Variability of Serum High-Density Lipoprotein Cholesterol
2012 (English)In: Twin Research and Human Genetics, ISSN 1832-4274, Vol. 15, no 6, 691-699 p.Article in journal (Refereed) Published
Genome-wide association analysis on monozygotic twin-pairs offers a route to discovery of gene-environment interactions through testing for variability loci associated with sensitivity to individual environment/lifestyle. We present a genome-wide scan of loci associated with intra-pair differences in serum lipid and apolipoprotein levels. We report data for 1,720 monozygotic female twin-pairs from GenomEUtwin project with 2.5 million SNPs, imputed or genotyped, and measured serum lipid fractions for both twins. We found one locus associated with intra-pair differences in high-density lipoprotein cholesterol, rs2483058 in an intron of SRGAP2, where twins carrying the C allele are more sensitive to environmental factors (P = 3.98 × 10-8). We followed up the association in further genotyped monozygotic twins (N = 1,261), which showed a moderate association for the variant (P = 0.200, same direction of an effect). In addition, we report a new association on the level of apolipoprotein A-II (P = 4.03 × 10-8).
Place, publisher, year, edition, pages
2012. Vol. 15, no 6, 691-699 p.
Medical and Health Sciences
IdentifiersURN: urn:nbn:se:uu:diva-188801DOI: 10.1017/thg.2012.63ISI: 000312502000001PubMedID: 23031429OAI: oai:DiVA.org:uu-188801DiVA: diva2:579267