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Signal transduction by vascular endothelial growth factor receptors
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Immunology, Genetics and Pathology, Cancer and Vascular Biology.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Immunology, Genetics and Pathology, Cancer and Vascular Biology.
2012 (English)In: Cold Spring Harbor perspectives in medicine, ISSN 2157-1422, Vol. 2, no 7, a006502- p.Article in journal (Refereed) Published
Abstract [en]

Vascular endothelial growth factors (VEGFs) are master regulators of vascular development and of blood and lymphatic vessel function during health and disease in the adult. It is therefore important to understand the mechanism of action of this family of five mammalian ligands, which act through three receptor tyrosine kinases (RTKs). In addition, coreceptors like neuropilins (NRPs) and integrins associate with the ligand/receptor signaling complex and modulate the output. Therapeutics to block several of the VEGF signaling components have been developed with the aim to halt blood vessel formation, angiogenesis, in diseases that involve tissue growth and inflammation, such as cancer. In this review, we outline the current information on VEGF signal transduction in relation to blood and lymphatic vessel biology.

Place, publisher, year, edition, pages
2012. Vol. 2, no 7, a006502- p.
National Category
Basic Medicine Cell and Molecular Biology
Identifiers
URN: urn:nbn:se:uu:diva-189021DOI: 10.1101/cshperspect.a006502ISI: 000314279100013PubMedID: 22762016OAI: oai:DiVA.org:uu-189021DiVA: diva2:580360
Available from: 2012-12-21 Created: 2012-12-21 Last updated: 2013-03-04Bibliographically approved

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Koch, SinaClaesson-Welsh, Lena

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