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Synchrotron radiation CT from the micro to nanoscale for the investigation of bone tissue
European Synchrotron Radiation Facility, Creatis, Université de Lyon .
European Synchrotron Radiation Facility, Creatis, Université de Lyon .
Uppsala University, Disciplinary Domain of Science and Technology, Mathematics and Computer Science, Department of Information Technology, Computerized Image Analysis and Human-Computer Interaction. Uppsala University, Disciplinary Domain of Science and Technology, Mathematics and Computer Science, Department of Information Technology, Division of Visual Information and Interaction. (Centre for Image Analysis)
European Synchrotron Radiation Facility, Creatis, Université de Lyon .
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2012 (English)In: Proceedings of SPIE: The International Society for Optical Engineering, 2012, 85060L- p.Conference paper, Published paper (Refereed)
Abstract [en]

During the last decade, X-ray micro Computerized Tomography (CT) has become a conventional technique for the threedimensional (3D) investigation of trabecular bone micro-architecture. Coupling micro-CT to synchrotron sources possesses significant advantages in terms of image quality and gives access to information on bone mineralization which is an important factor of bone quality. We present an overview of the investigation of bone using Synchrotron Radiation (SR) CT from the micro to the nano scale. We introduce two synchrotron CT systems developed at the ESRF based on SR parallel-beam micro-CT and magnified phase CT respectively, achieving down to submicrometric and nanometric spatial resolution. In the latter, by using phase retrieval prior to tomographic reconstruction, the system provides maps of the 3D refractive index distribution. Parallel-beam SR micro-CT has extensively been used for the analysis of trabecular or cortical bone in human or small animals with spatial resolution in the range [3-10] μm. However, the characterization of the bone properties at the cellular scale is also of major interest. At the micrometric scale, the shape, density and morphology of osteocyte lacunae can be studied on statistically representative volumes. At the nanometric scale, unprecedented 3D displays of the canaliculi network have been obtained on fields of views including a large number of interconnected osteocyte lacunae. Finally SR magnified phase CT provides a detailed analysis of the lacuno-canalicular network and in addition information on the organization of the collagen fibers. These findings open new perspectives for three-dimensional quantitative assessment of bone tissue at the cellular scale.

Place, publisher, year, edition, pages
2012. 85060L- p.
Series
Proceedings of SPIE - The International Society for Optical Engineering, ISSN 0277786X ; 8506
National Category
Signal Processing Medical Image Processing
Research subject
Computerized Image Processing
Identifiers
URN: urn:nbn:se:uu:diva-189043DOI: 10.1117/12.939473ISBN: 978-081949223-4 (print)OAI: oai:DiVA.org:uu-189043DiVA: diva2:580476
Conference
Developments in X-Ray Tomography, 13 August through 15 August, 2012, San Diego, CA
Available from: 2012-12-21 Created: 2012-12-21 Last updated: 2013-02-26Bibliographically approved

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Pacureanu, Alexandra

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Computerized Image Analysis and Human-Computer InteractionDivision of Visual Information and Interaction
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