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Parametric Images of Myocardial Viability Using a Single 15O-H2O PET/CT Scan
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2011 (English)In: Journal of Nuclear Medicine, ISSN 0161-5505, E-ISSN 1535-5667, Vol. 52, no 5, 745-749 p.Article in journal (Refereed) Published
Abstract [en]

Perfusable tissue index (PTI) is a marker of myocardial viability and requires acquisition of transmission, 15O-CO, and 15O-H2O scans. The aim of this study was to generate parametric PTI images from a 15O-H2O PET/CT scan without an additional 15O-CO scan.

Methods:

Data from 20 patients undergoing both 15O-H2O and 15O-CO scans were used, assessing correlation between PTI based on 15O-CO (PTICO) and on fitted blood volume fractions (PTIVb). In addition, parametric PTIVb images of 10 patients undergoing 15O-H2O PET/CT scans were generated using basis-function methods and compared with PTIVb obtained using nonlinear regression. Simulations were performed to study the effects of noise on PTIVb.

Results:

Correlation between PTICO and PTIVb was high (r2 = 0.73). Parametric PTIVb correlated well with PTIVb obtained using nonlinear regression (r2 = 0.91). Simulations showed low sensitivity to noise (coefficient of variation < 10% at 20% noise).

Conclusion:

Parametric PTI images can be generated from a single 15O-H2O PET/CT scan.

Place, publisher, year, edition, pages
2011. Vol. 52, no 5, 745-749 p.
National Category
Radiology, Nuclear Medicine and Medical Imaging
Identifiers
URN: urn:nbn:se:uu:diva-189079DOI: 10.2967/jnumed.110.085431PubMedID: 21498530OAI: oai:DiVA.org:uu-189079DiVA: diva2:580602
Available from: 2012-12-23 Created: 2012-12-23 Last updated: 2017-12-06Bibliographically approved

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Lubberink, Mark

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