uu.seUppsala University Publications
Change search
ReferencesLink to record
Permanent link

Direct link
Suicide seasonality and antidepressants: a register-based study in Sweden
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Neuroscience, Psychiatry, University Hospital.
Show others and affiliations
2013 (English)In: Acta Psychiatrica Scandinavica, ISSN 0001-690X, E-ISSN 1600-0447, Vol. 127, no 2, 117-125 p.Article in journal (Refereed) Published
Abstract [en]


Seasonality of completed suicides with a peak in spring and early summer is a well-documented finding. The circannual serotonergic functioning is hypothesized to be central in this phenomenon. Antidepressant medications exert their pharmacological action mainly by regulating serotonin. Our aim is to study the amplitude of the seasonal effect among suicide victims positive for different classes of antidepressants or without any antidepressants at the time of death.


By using Swedish Registers, 12 448 suicides with forensic data for antidepressive medication and information on in-patient-treated mental disorder were identified during 1992-2003. Seasonality was estimated with a Poisson regression variant of the circular normal distribution of completed suicides.


Higher suicide seasonality was found for individuals treated with selective serotonin reuptake inhibitor (SSRIs) compared to those with other antidepressant treatment or without any antidepressant treatment. The finding is more evident for men and violent suicide methods and those without history of in-patient treatment.


Our results provide preliminary support for the serotonergic hypothesis of suicide seasonality and raise the question of a possible accentuation of the natural suicide seasonality in patients treated with SSRIs, a hypothesis that warrants further investigation.

Place, publisher, year, edition, pages
2013. Vol. 127, no 2, 117-125 p.
National Category
URN: urn:nbn:se:uu:diva-189178DOI: 10.1111/j.1600-0447.2012.01891.xISI: 000313492300004PubMedID: 22676408OAI: oai:DiVA.org:uu-189178DiVA: diva2:580728
Available from: 2012-12-25 Created: 2012-12-25 Last updated: 2013-11-22Bibliographically approved

Open Access in DiVA

No full text

Other links

Publisher's full textPubMed

Search in DiVA

By author/editor
Makris, Georgios D.Papadopoulos, F C
By organisation
Psychiatry, University Hospital
In the same journal
Acta Psychiatrica Scandinavica

Search outside of DiVA

GoogleGoogle Scholar
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

Altmetric score

Total: 155 hits
ReferencesLink to record
Permanent link

Direct link