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In Vivo Visualization of Amyloid Deposits in the Heart with 11C-PIB and PET
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Pharmacy, Department of Medicinal Chemistry, Preclinical PET Platform.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Radiology, Oncology and Radiation Science, Section of Nuclear Medicine and PET.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Pharmacy, Department of Medicinal Chemistry, Preclinical PET Platform.
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2013 (English)In: Journal of Nuclear Medicine, ISSN 0161-5505, E-ISSN 1535-5667, Vol. 54, no 2, 213-220 p.Article in journal (Refereed) Published
Abstract [en]

Cardiac amyloidosis is a differential diagnosis in heart failure and is associated with high mortality. There is currently no noninvasive imaging test available for specific diagnosis. N-[methyl-11C]2-(4′-methylamino-phenyl)-6-hydroxybenzothiazole (11C-PIB) PET is used in the evaluation of brain amyloidosis. We evaluated the potential use of 11C-PIB PET in systemic amyloidosis affecting the heart.

Methods:

Patients (n = 10) diagnosed with systemic amyloidosis—including heart involvement of either monoclonal immunoglobulin light-chain (AL) or transthyretin (ATTR) type—and healthy volunteers (n = 5) were investigated with PET/CT using 11C-PIB to study cardiac amyloid deposits and with 11C-acetate to measure myocardial blood flow to study the impact of global and regional perfusion on PIB retention.

Results:

Myocardial 11C-PIB uptake was visually evident in all patients 15–25 min after injection and was not seen in any volunteer. A significant difference in 11C-PIB retention in the heart between patients and healthy controls was found. The data indicate that myocardial amyloid deposits in patients diagnosed with systemic amyloidosis could be visualized with 11C-PIB. No correlation between 11C-PIB retention index and myocardial blood flow as measured with 11C-acetate was found on the global level, whereas a positive correlation on the segmental level was seen in a single patient.

Conclusion:

11C-PIB and PET could be a method to study systemic amyloidosis of type AL and ATTR affecting the heart and should be investigated further both as a diagnostic tool and as a noninvasive method for treatment follow-up.

Place, publisher, year, edition, pages
2013. Vol. 54, no 2, 213-220 p.
National Category
Radiology, Nuclear Medicine and Medical Imaging
Identifiers
URN: urn:nbn:se:uu:diva-189479DOI: 10.2967/jnumed.111.102053ISI: 000314691200021PubMedID: 23238792OAI: oai:DiVA.org:uu-189479DiVA: diva2:581546
Available from: 2013-01-02 Created: 2013-01-02 Last updated: 2017-12-06Bibliographically approved

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Antoni, GunnarLubberink, MarkEstrada, SergioKero, TanjaLångström, BengtGranstam, Sven-OlofRosengren, SaraVedin, OlaWassberg, CeciliaWikström, GerhardWestermark, PerSörensen, Jens

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Antoni, GunnarLubberink, MarkEstrada, SergioCarlson, KristinaKero, TanjaLångström, BengtGranstam, Sven-OlofRosengren, SaraVedin, OlaWassberg, CeciliaWikström, GerhardWestermark, PerSörensen, Jens
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Preclinical PET PlatformSection of Nuclear Medicine and PETHaematologyDepartment of Biochemistry and Organic ChemistryClinical PhysiologyDepartment of Medical SciencesUCR-Uppsala Clinical Research CenterCardiologyMolecular and Morphological Pathology
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Journal of Nuclear Medicine
Radiology, Nuclear Medicine and Medical Imaging

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