Aminocarbonylations Employing Mo(CO)(6) and a Bridged Two-Vial System: Allowing the Use of Nitro Group Substituted Aryl Iodides and Aryl Bromides
2012 (English)In: Journal of Organic Chemistry, ISSN 0022-3263, E-ISSN 1520-6904, Vol. 77, no 24, 11393-11398 p.Article in journal (Refereed) Published
A bridged two-vial system aminocarbonylation protocol where Mo(CO)(6) functions as an external in situ solid source of CO has been developed. For the first time both nitro group containing aryl/heteroaryl iodides and bromides gave good to excellent yields in the Mo(CO)(6)-mediated and palladium(0)-catalyzed conversion to benzamides, while the identical one-vessel protocol afforded extensive reduction of the nitro functionality. The above-mentioned bridged two-compartment protocol furnished good results with both primary amines and secondary amines and sluggish aniline nucleophiles at 65-85 °C reaction temperatures.
Place, publisher, year, edition, pages
2012. Vol. 77, no 24, 11393-11398 p.
Medicinal Chemistry Natural Sciences
IdentifiersURN: urn:nbn:se:uu:diva-189519DOI: 10.1021/jo302322wISI: 000312564900046PubMedID: 23205569OAI: oai:DiVA.org:uu-189519DiVA: diva2:581754
FunderKnut and Alice Wallenberg FoundationSwedish Research Council