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Deuterostomic Development in the Protostome Priapulus caudatus
Uppsala University, Disciplinary Domain of Science and Technology, Earth Sciences, Department of Earth Sciences, Palaeobiology.
Uppsala University, Disciplinary Domain of Science and Technology, Earth Sciences, Department of Earth Sciences, Palaeobiology.
Uppsala University, Disciplinary Domain of Science and Technology, Earth Sciences, Department of Earth Sciences, Palaeobiology.
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2012 (English)In: Current Biology, ISSN 0960-9822, E-ISSN 1879-0445, Vol. 22, no 22, 2161-2166 p.Article in journal (Refereed) Published
Abstract [en]

The fate of the blastopore during development in the bilaterian ancestor is currently not well understood. In deuterostomes, the blastopore forms the anus, but its fate in protostome groups is variable [1]. This variability, combined with an absence of information from key taxa, hampers the reconstruction of the ancestral developmental mode of the Protostomia and the Bilateria. The blastopore fate of the bilaterian ancestor plays a crucial role in understanding the transition from radial to bilateral symmetric organisms [2, 3]. Priapulids have a conservative morphology, an abundant Cambrian fossil record, and a phylogenetic position that make them a key group in understanding protostome evolution [4, 5]. Here, we characterize gastrulation and the embryonic expression of genes involved in bilaterian foregut and hindgut patterning in Priapulus caudatus. We show that the blastopore gives rise to the anus at the vegetal pole and that the hindgut markers brachyury and caudal are expressed in the blastopore and anus, whereas the foregut markers foxA and goosecoid are expressed in the mouth in the animal hemisphere. Thereby, gastrulation in the conservatively evolving protostome P. caudatus follows strictly a deuterostomic pattern. These results are more compatible with a deuterostomic rather than protostomic (blastopore forms the mouth) or amphistomic (mouth and anus are formed simultaneously) mode of development in the last common bilaterian ancestor.

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2012. Vol. 22, no 22, 2161-2166 p.
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Natural Sciences
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URN: urn:nbn:se:uu:diva-189148DOI: 10.1016/j.cub.2012.09.037ISI: 000311523800026OAI: oai:DiVA.org:uu-189148DiVA: diva2:582099
Available from: 2013-01-03 Created: 2012-12-25 Last updated: 2017-12-06Bibliographically approved

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Janssen, RalfBudd, Graham E.

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