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Results from the scandinavian prostate cancer group trial number 4: a randomized controlled trial of radical prostatectomy versus watchful waiting
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Surgical Sciences, Endocrine Surgery.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Surgical Sciences, Urology.
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2012 (English)In: Journal of the National Cancer Institute. Monographs, ISSN 1052-6773, E-ISSN 1745-6614, Vol. 2012, no 45, 230-233 p.Article in journal (Refereed) Published
Abstract [en]

In the Scandinavian Prostate Cancer Group Trial Number 4 (SPCG-4), 347 men were randomly assigned to radical prostatectomy and 348 to watchful waiting. In the most recent analysis (median follow-up time = 12.8 years), the cumulative mortality curves had been stable over the follow-up. At 15 years, the absolute risk reduction of dying from prostate cancer was 6.1% following randomization to radical prostatectomy, compared with watchful waiting. Hence, 17 need to be randomized to operation to avert one death. Data on self-reported symptoms, stress from symptoms, and quality of life were collected at 4 and 12.2 years of median follow-up. These questionnaire studies show an intricate pattern of symptoms evolving after surgery, hormonal treatments, signs of tumor progression, and also from natural aging. This article discusses some of the main findings of the SPCG-4 study.

Place, publisher, year, edition, pages
2012. Vol. 2012, no 45, 230-233 p.
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Medical and Health Sciences
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URN: urn:nbn:se:uu:diva-189783DOI: 10.1093/jncimonographs/lgs025PubMedID: 23271778OAI: oai:DiVA.org:uu-189783DiVA: diva2:582271
Available from: 2013-01-04 Created: 2013-01-04 Last updated: 2017-12-06Bibliographically approved

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Holmberg, LarsBill-Axelson, AnnaJohansson, Eva

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