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Hormonal therapies and meningioma: is there a link?
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Public Health and Caring Sciences, Family Medicine and Preventive Medicine.
2012 (English)In: Cancer epidemiology, ISSN 1877-783X, Vol. 36, no 2, 198-205 p.Article in journal (Refereed) Published
Abstract [en]

BACKGROUND: The aetiology of meningiomas is largely unknown although hormones have been suggested to play a role.

METHODS: A cohort study was performed to evaluate hormone-related factors associated with meningioma. Patients (12-89 years) with a first diagnosis of meningioma (January 1996-June 2008) were identified from The Health Improvement Network UK primary care database and age- and sex-matched to controls (n=10000) from the same cohort. Odds ratios (ORs) were calculated following a nested case control analysis using unconditional logistic regression.

RESULTS: In total, 745 patients with meningioma were identified from a study population of 2171287. No significantly increased risk of meningioma was found among female users of oral contraceptives (OR: 1.15; CI: 0.67-1.98), hormone replacement therapy (OR: 0.99; CI: 0.73-1.35) or low-dose cyproterone acetate (CPA; OR: 1.51; CI: 0.33-6.86) compared with non-users. There was a significantly increased risk of meningioma among male users of androgen analogues (OR: 19.09; CI: 2.81-129.74) and among users of high-dose CPA (OR: 6.30; CI: 1.37-28.94) compared with non-users, however there were only three cases currently using these drugs. No significant association was found between meningioma and prostate, breast, or genital cancers.

CONCLUSIONS: Our results do not support a role for exogenous hormone use by females in meningioma development. The risk in males was only observed with high-dose, short-term (<1 year) therapy.

IMPACT: While hormonal cancers and therapies are not associated with meningioma in females, the risk in males requires further investigation.

Place, publisher, year, edition, pages
2012. Vol. 36, no 2, 198-205 p.
National Category
Public Health, Global Health, Social Medicine and Epidemiology
URN: urn:nbn:se:uu:diva-189806DOI: 10.1016/j.canep.2011.08.003ISI: 000303240800030PubMedID: 21943794OAI: oai:DiVA.org:uu-189806DiVA: diva2:582329
Available from: 2013-01-04 Created: 2013-01-04 Last updated: 2015-08-11Bibliographically approved

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