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High-resolution protein structure determination by serial femtosecond crystallography
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2012 (English)In: Science, ISSN 0036-8075, E-ISSN 1095-9203, Vol. 337, no 6092, 362-364 p.Article in journal (Refereed) Published
Abstract [en]

Structure determination of proteins and other macromolecules has historically required the growth of high-quality crystals sufficiently large to diffract x-rays efficiently while withstanding radiation damage. We applied serial femtosecond crystallography (SFX) using an x-ray free-electron laser (XFEL) to obtain high-resolution structural information from microcrystals (less than 1 micrometer by 1 micrometer by 3 micrometers) of the well-characterized model protein lysozyme. The agreement with synchrotron data demonstrates the immediate relevance of SFX for analyzing the structure of the large group of difficult-to-crystallize molecules.

Place, publisher, year, edition, pages
2012. Vol. 337, no 6092, 362-364 p.
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Structural Biology
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URN: urn:nbn:se:uu:diva-189893DOI: 10.1126/science.1217737ISI: 000306542600057PubMedID: 22653729OAI: oai:DiVA.org:uu-189893DiVA: diva2:582545
Available from: 2013-01-04 Created: 2013-01-04 Last updated: 2017-12-06Bibliographically approved

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Seibert, M MarvinCaleman, CarlTimneanu, Nicusor

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