Long-term follow-up of a large series of patients with type 1 gastric carcinoid tumors: Data from a multicenter study
2013 (English)In: European Journal of Endocrinology, ISSN 0804-4643, E-ISSN 1479-683X, Vol. 168, no 2, 185-193 p.Article in journal (Refereed) Published
To study the clinical presentation, diagnostic approach, response to treatment and the presence of other pathologies in patients with gastric carcinoid type-1 tumors (GC-1).
DESIGN AND METHODS:
Retrospective analysis of 111 patients from 4 institutions and a mean follow-up of 76 months.
The main indications for gastroscopy were upper gastrointestinal tract symptoms. The mean number of lesions, maximum tumoral diameter and percentage of cells expressing Κi-67 labeling index were 3.6±3.8, 8±12.1mm and 1.9±2.4%, respectively. Serum gastrin and chromogranin A (CgA) levels were elevated in 100/101 and 85/90 patients, respectively. Conventional imaging studies demonstrated pathology in 9/111 patients. Scintigraphy with radiolabelled octreotide was positive in 6/60 without revealing any additional lesions. From the 59 patients who had been followed-up without any intervention 5 developed tumor progression. Thirty-two patients were treated with long acting somatostatin analogues (SSAs), leading to a significant reduction of gastrin and CgA levels, number of visible tumors and CgA immune reactive tumor cells in 28, 19, 27, and 23 treated patients respectively. Antrectomy and/or gastrectomy was initially performed in 20 patients and a complete response was achieved in 13 patients. The most common co-morbidities were vitamin B12 deficiency, thyroiditis and parathyroid adenomas.
Most GCs-1 are grade 1 (82.72%) tumors presenting with stage I (73.87%) disease with no mortality after prolonged follow-up. Ocreoscan did not provide further information compared to conventional imaging techniques. Treatment with SSAs proved to be effective for the duration of administration.
Place, publisher, year, edition, pages
2013. Vol. 168, no 2, 185-193 p.
gastric carcinoids type-1
Medical and Health Sciences
Research subject Oncology; Endocrinology and Diabetology
IdentifiersURN: urn:nbn:se:uu:diva-189948DOI: 10.1530/EJE-12-0836ISI: 000315577400015PubMedID: 23132699OAI: oai:DiVA.org:uu-189948DiVA: diva2:582588