uu.seUppsala University Publications
Change search
ReferencesLink to record
Permanent link

Direct link
G Protein-Coupled Receptor Deorphanizations
Show others and affiliations
2013 (English)In: Annual Review of Pharmacology and Toxicology, ISSN 0362-1642, E-ISSN 1545-4304, Vol. 53, 127-146 p.Article, review/survey (Refereed) Published
Abstract [en]

G protein-coupled receptors (GPCRs) are major regulators of intercellular interactions. They initiate these actions by being activated by a wide variety of natural ligands. Historically, ligands were discovered first, but the advent of molecular biology reversed this trend. Most GPCRs are identified on the basis of their DNA sequences and thus are initially unmatched to known natural ligands. They are termed orphan GPCRs. Discovering their ligands-i.e., "deorphanizing" the GPCRs-gave birth to the field of reverse pharmacology. This review discusses the present status of GPCR deorphanization, presents a few examples of successes and surprises, and highlights difficulties encountered in these efforts.

Place, publisher, year, edition, pages
2013. Vol. 53, 127-146 p.
National Category
Medical and Health Sciences
URN: urn:nbn:se:uu:diva-190100DOI: 10.1146/annurev-pharmtox-010611-134548ISI: 000323040100007PubMedID: 23020293OAI: oai:DiVA.org:uu-190100DiVA: diva2:582996
Available from: 2013-01-07 Created: 2013-01-07 Last updated: 2013-10-08Bibliographically approved

Open Access in DiVA

No full text

Other links

Publisher's full textPubMed

Search in DiVA

By author/editor
Fredriksson, RobertSchiöth, Helgi B
By organisation
Functional Pharmacology
In the same journal
Annual Review of Pharmacology and Toxicology
Medical and Health Sciences

Search outside of DiVA

GoogleGoogle Scholar
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

Altmetric score

Total: 267 hits
ReferencesLink to record
Permanent link

Direct link