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Omega-3 fatty acids: Benefits for cardio-cerebro-vascular diseases
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Pharmacy, Department of Pharmacy.
2012 (English)In: Atherosclerosis, ISSN 0021-9150, E-ISSN 1879-1484, Vol. 225, no 2, 291-295 p.Article in journal, Editorial material (Other academic) Published
Abstract [en]

Background and purpose: Intracranial artery stenosis (ICAS) is a narrowing of an intracranial artery, which is a common etiology for ischemic stroke. In this commentary, we review key aspects of the discrimination between non-stroke controls and ischemic stroke patients on the background of phospholipid omega 3-fatty acid (DHA, EPA) composition. The discussion is embedded in the presentation of general effects of long-chain omega 3 polyunsaturated fatty acids (PUFAs) in cardio-cerebro-vascular diseases (CCVDs) and Alzheimer dementia (AD). Summary of commentary: ICAS is a common stroke subtype and has emerged as a major factor in recurrent stroke and vascular mortality. DHA and EPA are important fatty acids to distinguish between NCAS (no cerebral arteriosclerotic stenosis) and ICAS in stroke. The risk of ICAS is inversely correlated with the DHA content in phospholipids. Furthermore, a mechanistic explanation has been proposed for the beneficial effects of PUFAs in CCVDs and AD. Conclusions: Whereas the beneficial effects of EPA/DHA for cardiovascular diseases and stroke seem to be beyond question, preventive effects in patients with very mild cognitive dysfunction and beginning Alzheimer's disease undoubtedly need confirmation by larger clinical trials. A collaborative international basic science approach is warranted considering cautiously designed studies in order to avoid ethical problems. (C) 2012 Elsevier Ireland Ltd. All rights reserved.

Place, publisher, year, edition, pages
2012. Vol. 225, no 2, 291-295 p.
Keyword [en]
Omega-3 fatty acids, Cardiovascular diseases, Stroke and subtypes, Alzheimer dementia
National Category
Medical and Health Sciences
URN: urn:nbn:se:uu:diva-190133DOI: 10.1016/j.atherosclerosis.2012.09.006ISI: 000311344700028OAI: oai:DiVA.org:uu-190133DiVA: diva2:583395
Available from: 2013-01-07 Created: 2013-01-07 Last updated: 2013-01-07Bibliographically approved

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Siegel, Günter
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