uu.seUppsala University Publications
Change search
ReferencesLink to record
Permanent link

Direct link
Microglial Markers are Elevated in the Prodromal Phase of Alzheimer's Disease and Vascular Dementia
Show others and affiliations
2013 (English)In: Journal of Alzheimer's Disease, ISSN 1387-2877, Vol. 33, no 1, 45-53 p.Article in journal (Refereed) Published
Abstract [en]

Microglia manage immunosurveillance and mediate inflammation, both suggested to be important in Alzheimer's disease (AD). The aim of this study was to investigate if microglial markers could differentiate, firstly between AD and controls, and secondly between stable mild cognitive impairment (MCI) and those progressing to AD and vascular dementia (VaD). Furthermore, we investigated if these markers were sufficiently stable to be used in clinical trials. We quantified YKL-40 and sCD14 in cerebrospinal fluid (CSF) from 96 AD patients, 65 healthy controls, and 170 patients with MCI from baseline and over 5.7 years. For the stability analysis, two CSF samples were collected from 52 AD patients with a six-month interval in between. YKL-40, but not sCD14, was significantly elevated in AD compared with healthy controls (p = 0.003). Furthermore, YKL-40 and sCD14 were increased in MCI patients who converted to VaD (p = 0.029 and p = 0.008), but not to AD according to NINCDS-ADRDA. However, when stratified according to CSF levels of tau and Aβ42, YKL-40 was elevated in those with an AD-indicative profile compared with stable MCI with a normal profile (p = 0.037). In addition, YKL-40 and sCD14 were very stable in AD patients with good correlation between time-points (r = 0.94, p = 3.4 × 10-25; r = 0.77, p = 2.0 × 10-11) and the cortical damage marker T-tau. Thus, microglial markers are stable and may be used as safety markers for monitoring CNS inflammation and microglia activation in clinical trials. Moreover, YKL-40 differentiates between AD and controls and between stable MCI to AD and those that convert to AD and VaD.

Place, publisher, year, edition, pages
2013. Vol. 33, no 1, 45-53 p.
National Category
URN: urn:nbn:se:uu:diva-190427DOI: 10.3233/JAD-2012-120787ISI: 000312154400007PubMedID: 22890100OAI: oai:DiVA.org:uu-190427DiVA: diva2:583481
Available from: 2013-01-08 Created: 2013-01-08 Last updated: 2013-01-10Bibliographically approved

Open Access in DiVA

No full text

Other links

Publisher's full textPubMed

Search in DiVA

By author/editor
Lannfelt, Lars
By organisation
In the same journal
Journal of Alzheimer's Disease

Search outside of DiVA

GoogleGoogle Scholar
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

Altmetric score

Total: 234 hits
ReferencesLink to record
Permanent link

Direct link