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Role of leptin in energy balance and sexual maturation in male Atlantic salmo (Salmo salar L.) parr
Uppsala University, Disciplinary Domain of Science and Technology, Biology, Department of Organismal Biology, Comparative Physiology.
2012 (English)Licentiate thesis, comprehensive summary (Other academic)
Place, publisher, year, edition, pages
Uppsala: Department of Organismal Biology, Uppsala University , 2012. , 25 p.
Keyword [en]
leptin, leptin receptor, sexual maturation, restricted feeding, Atlantic salmon
National Category
Zoology
Research subject
Biology with specialization in Comparative Physiology
Identifiers
URN: urn:nbn:se:uu:diva-190203OAI: oai:DiVA.org:uu-190203DiVA: diva2:584994
Presentation
2012-06-14, Seminar room 05:1021, Evolutionsbiologiskt centrum,Norbyvägen 18A, Uppsala, 10:00 (English)
Opponent
Supervisors
Funder
Formas, 221-2006-1534
Available from: 2013-01-10 Created: 2013-01-07 Last updated: 2013-01-10Bibliographically approved
List of papers
1. Effects of long-term restricted feeding on plasma leptin, hepatic leptin expression and leptin receptor expression in juvenile Atlantic salmon (Salmo salar L.)
Open this publication in new window or tab >>Effects of long-term restricted feeding on plasma leptin, hepatic leptin expression and leptin receptor expression in juvenile Atlantic salmon (Salmo salar L.)
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2012 (English)In: General and Comparative Endocrinology, ISSN 0016-6480, E-ISSN 1095-6840, Vol. 175, no 1, 92-99 p.Article in journal (Refereed) Published
Abstract [en]

Leptin is a pleiotropic hormone and plays a key role in body weight regulation, energy homeostasis and lipid store utilization in mammals. In this study, we investigated the effect of feed-restriction on leptin genes (lepa1 and lepa2), leptin receptor (lepr) gene expression and plasma leptin levels in juvenile Atlantic salmon parr. Feed restriction was performed from late April to mid-June, in order to gain insight into the role of the leptin system in energy balance regulation and adiposity in juvenile salmon. A significant increase in lepa1 expression as well as higher levels of plasma leptin was found in feed-restricted fish in June compared to fully fed controls, while lepa2 gene expression decreased in both groups during the treatment period. Lepa2 was, however significantly higher in the feed-restricted group in June. Leptin receptor expression was up regulated during the period of enhanced growth and lipid deposition in the fully fed control, indicating a seasonal effect on the receptor expression in the brain. Both lepa1 and lepa2 genes very mainly expressed in the liver in juvenile salmon, while lepr was expressed in the brain but showed also considerable expression in various peripheral tissues. The study provides evidence that the leptin system is sensitive to the metabolic status of the fish as both season and restricted feeding affect lepa1 and lepa2 gene expression in the liver and brain leptin receptor expression, however, for lepa1 expression and leptin plasma level in an opposite way as that observed in the mammalian system.

National Category
Zoology
Research subject
Biology with specialization in Comparative Physiology
Identifiers
urn:nbn:se:uu:diva-166581 (URN)10.1016/j.ygcen.2011.10.001 (DOI)000299065800012 ()22019478 (PubMedID)
Funder
Formas, 2010-03-11
Available from: 2012-01-12 Created: 2012-01-12 Last updated: 2014-06-30Bibliographically approved

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