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Heparan Sulfate Biosynthesis: Regulation and Variability
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Biochemistry and Microbiology. Uppsala University, Science for Life Laboratory, SciLifeLab.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Biochemistry and Microbiology. Uppsala University, Science for Life Laboratory, SciLifeLab.
2012 (English)In: Journal of Histochemistry and Cytochemistry, ISSN 0022-1554, E-ISSN 1551-5044, Vol. 60, no 12, 898-907 p.Article in journal (Refereed) Published
Abstract [en]

Nearly all vertebrate cells have been shown to express heparan sulfate proteoglycans (HSPGs) at the cell surface. The HSPGs bind to many secreted signaling proteins, including numerous growth factors, cytokines, and morphogens, to affect their tissue distribution and signaling. The heparan sulfate (HS) chains may have variable length and may differ with regard to both degree and pattern of sulfation. As the sulfation pattern of HS chains in most cases will determine if an interaction with a potential ligand will take place, as well as the affinity of the interaction, a key to understanding the function of HSPGs is to clarify how HS biosynthesis is regulated in different biological contexts. This review provides an introduction to the current understanding of HS biosynthesis and its regulation, and identifies research areas where more knowledge is needed to better understand how the HS biosynthetic machinery works. (J Histochem Cytochem 60:898-907, 2012)

Place, publisher, year, edition, pages
2012. Vol. 60, no 12, 898-907 p.
Keyword [en]
heparan sulfate, biosynthesis, regulation, enzyme, specificity, GAGosome, Golgi
National Category
Medical and Health Sciences
Identifiers
URN: urn:nbn:se:uu:diva-190325DOI: 10.1369/0022155412464972ISI: 000311683500002OAI: oai:DiVA.org:uu-190325DiVA: diva2:585875
Available from: 2013-01-10 Created: 2013-01-07 Last updated: 2017-12-06Bibliographically approved

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Kreuger, JohanKjellén, Lena

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