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Bridging the gap between ribosome structure and biochemistry by mechanistic computations
Uppsala University, Disciplinary Domain of Science and Technology, Biology, Department of Cell and Molecular Biology, Computational and Systems Biology.
Uppsala University, Disciplinary Domain of Science and Technology, Biology, Department of Cell and Molecular Biology, Computational and Systems Biology.
Uppsala University, Disciplinary Domain of Science and Technology, Biology, Department of Cell and Molecular Biology, Computational and Systems Biology.
2012 (English)In: Current opinion in structural biology, ISSN 0959-440X, E-ISSN 1879-033X, Vol. 22, no 6, 815-823 p.Article in journal (Refereed) Published
Abstract [en]

The wealth of structural and biochemical data now available for protein synthesis on the ribosome presents major new challenges for computational biochemistry. Apart from technical difficulties in modeling ribosome systems, the complexity of the overall translation cycle with a multitude of different kinetic steps presents a formidable problem for computational efforts where we have only seen the beginning. However, a range of methodologies including molecular dynamics simulations, free energy calculations, molecular docking and quantum chemical approaches have already been put to work with promising results. In particular, the combined efforts of structural biology, biochemistry, kinetics and computational modeling can lead towards a quantitative structure-based description of translation.

Place, publisher, year, edition, pages
2012. Vol. 22, no 6, 815-823 p.
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Natural Sciences
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URN: urn:nbn:se:uu:diva-191777DOI: 10.1016/j.sbi.2012.07.008ISI: 000312421000016OAI: oai:DiVA.org:uu-191777DiVA: diva2:588208
Available from: 2013-01-15 Created: 2013-01-14 Last updated: 2017-12-06Bibliographically approved

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Aqvist, JohanLind, ChristofferSund, Johan

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