uu.seUppsala University Publications
Change search
ReferencesLink to record
Permanent link

Direct link
Amphiphilic star-shaped block copolymers as unimolecular drug delivery systems: investigations using a novel fungicide
Show others and affiliations
2013 (English)In: Soft Matter, ISSN 1744-683X, Vol. 9, no 3, 715-726 p.Article in journal (Refereed) Published
Abstract [en]

Amphiphilic star-shaped poly(epsilon-caprolactone)-block-poly(oligo(ethylene glycol) methacrylate) [PCLa-b-POEGMA(b)](4) block copolymers with four arms and varying degrees of polymerization for the core (PCL) and the shell (POEGMA) were used to investigate the solution behavior in dilute aqueous solution using a variety of techniques, including fluorescence and UV/Vis spectroscopy, dynamic light scattering, analytical ultracentrifugation, and isothermal titration calorimetry. Particular emphasis has been applied to prove that the systems form unimolecular micelles for different hydrophilic/lipophilic balances of the employed materials. In vitro cytotoxicity and hemocompatibility have further been investigated to probe the suitability of these structures for in vivo applications. A novel fungicide was included into the hydrophobic core in aqueous media to test their potential as drug delivery systems. After loading, the materials have been shown to release the drug and to provoke therewith an inhibition of the growth of different fungal strains.

Place, publisher, year, edition, pages
2013. Vol. 9, no 3, 715-726 p.
National Category
Natural Sciences
URN: urn:nbn:se:uu:diva-191765DOI: 10.1039/c2sm26509eISI: 000312335500012OAI: oai:DiVA.org:uu-191765DiVA: diva2:588364
Available from: 2013-01-15 Created: 2013-01-14 Last updated: 2013-01-15Bibliographically approved

Open Access in DiVA

No full text

Other links

Publisher's full text
By organisation
Department of Chemistry - BMC
In the same journal
Soft Matter
Natural Sciences

Search outside of DiVA

GoogleGoogle Scholar
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

Altmetric score

Total: 192 hits
ReferencesLink to record
Permanent link

Direct link