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Oligodendroglioma models
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Immunology, Genetics and Pathology.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Immunology, Genetics and Pathology, Cancer and Vascular Biology.
2013 (English)In: Animal Models of Brain Tumors / [ed] Ricardo Martínez Murillo, Alfredo Martínez, Humana Press, 2013, 57-82 p.Chapter in book (Refereed)
Abstract [en]

Oligodendroglial tumors are primary tumors of the central nervous system that largely affect adults. The cell of origin is undefined, but the tumors display many features reminiscent of oligodendrocytes or oligodendrocyte progenitor cells. Here, we briefly recapitulate the history of oligodendroglial tumor research, discuss the current knowledge concerning the biology of oligodendroglial tumors, and thoroughly review the various mouse models that have been used and that are currently in use to study oligodendroglial tumor development.

Place, publisher, year, edition, pages
Humana Press, 2013. 57-82 p.
Series
Neuromethods, ISSN 0893-2336 ; 77
Keyword [en]
CNPase, Epidermal growth factor receptor (EGFR), Mouse model, NG2, OLIG2, Oligodendrocyte, Oligodendrocyte progenitor cell (OPC), Oligodendroglioma, Platelet-derived growth factor receptor alpha (PDGFRA)
National Category
Medical and Health Sciences
Identifiers
URN: urn:nbn:se:uu:diva-192050DOI: 10.1007/7657_2012_35ISBN: 9781627032087 (print)OAI: oai:DiVA.org:uu-192050DiVA: diva2:589509
Available from: 2013-01-18 Created: 2013-01-15 Last updated: 2013-01-18Bibliographically approved

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Uhrbom, Lene

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