uu.seUppsala University Publications
Change search
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf
Circulating levels of persistent organic pollutants are related to retrospective assessment of life-time weight change
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Occupational and Environmental Medicine.ORCID iD: 0000-0002-8949-3555
Show others and affiliations
2013 (English)In: Chemosphere, ISSN 0045-6535, E-ISSN 1879-1298, Vol. 90, no 3, 998-1004 p.Article in journal (Refereed) Published
Abstract [en]

Background: Persistent organic pollutants (POPs) have been suggested to be linked to obesity. We have previously shown that less-chlorinated PCBs were positively related to fat mass, while highly-chlorinated PCBs were inversely related to obesity.Objective: The aim of the present evaluation is to investigate the relationship between retrospective assessed life-time change in body weight (20-70. years) with circulating POP levels measured at age 70. years.Methods: 1016 subjects aged 70. years were investigated in the Prospective Investigation of the Vasculature in Uppsala Seniors (PIVUSs) study. 16 PCBs and 3 OC pesticides were analyzed using HRGC/HRMS. Current body weight was measured and participants self-reported their weight at age 20.Results: The average estimated weight change over 50. years was 14.4. kg. Both the sum of OC pesticide concentrations (4.3. kg more weight gain in quintile 5 vs. quintile 1, p< 0.0001) and the sum of the less-chlorinated PCBs were positively related to the estimated weight change (3.7. kg more weight gain in quintile 2 vs. quintile 1, non-linear relationship p=0.0015). In contrast, the sum of concentrations of highly-chlorinated PCBs were inversely related to estimated weight change (8.4. kg less weight gain in quintile 5 vs. quintile 1, p< 0.0001).Conclusion: High levels of OC pesticides and the less-chlorinated PCBs at age 70 were associated with a pronounced estimated weight change over the previous 50. years. However, the opposite was seen for highly-chlorinated PCBs. Differences in mode of action, toxicokinetics, non-linear relationships and reverse causation might explain these discrepancies.

Place, publisher, year, edition, pages
2013. Vol. 90, no 3, 998-1004 p.
Keyword [en]
Elderly, Fat mass, Life time weight change, Obesity, Persistent organic pollutants, Life-times, Persistent organic pollutant (POP), Anthropometry, Nutrition, Pesticides, Polychlorinated biphenyls, Organic pollutants, benzene derivative, organic compound, organochlorine pesticide, polybrominated diphenyl ether, polychlorinated biphenyl, body mass, chlorinated hydrocarbon, concentration (composition), elderly population, health impact, organic pollutant, PCB, persistence, pesticide, pollution exposure, toxicology, age, aged, article, female, human, major clinical study, male, mass spectrometry, organic pollution, self report, toxicokinetics, weight change, weight gain, Sweden, Uppsala [Sweden]
National Category
Medical and Health Sciences
Identifiers
URN: urn:nbn:se:uu:diva-192048DOI: 10.1016/j.chemosphere.2012.07.051ISI: 000312978700016OAI: oai:DiVA.org:uu-192048DiVA: diva2:589524
Available from: 2013-01-18 Created: 2013-01-15 Last updated: 2017-12-06Bibliographically approved

Open Access in DiVA

No full text

Other links

Publisher's full text

Authority records BETA

Lind, Monica P.Lind, Lars

Search in DiVA

By author/editor
Lind, Monica P.Lind, Lars
By organisation
Occupational and Environmental MedicineCardiovascular epidemiology
In the same journal
Chemosphere
Medical and Health Sciences

Search outside of DiVA

GoogleGoogle Scholar

doi
urn-nbn

Altmetric score

doi
urn-nbn
Total: 367 hits
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf