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Circulating levels of persistent organic pollutants are related to retrospective assessment of life-time weight change
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Occupational and Environmental Medicine.
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2013 (English)In: Chemosphere, ISSN 0045-6535, E-ISSN 1879-1298, Vol. 90, no 3, 998-1004 p.Article in journal (Refereed) Published
Abstract [en]

Background: Persistent organic pollutants (POPs) have been suggested to be linked to obesity. We have previously shown that less-chlorinated PCBs were positively related to fat mass, while highly-chlorinated PCBs were inversely related to obesity.Objective: The aim of the present evaluation is to investigate the relationship between retrospective assessed life-time change in body weight (20-70. years) with circulating POP levels measured at age 70. years.Methods: 1016 subjects aged 70. years were investigated in the Prospective Investigation of the Vasculature in Uppsala Seniors (PIVUSs) study. 16 PCBs and 3 OC pesticides were analyzed using HRGC/HRMS. Current body weight was measured and participants self-reported their weight at age 20.Results: The average estimated weight change over 50. years was 14.4. kg. Both the sum of OC pesticide concentrations (4.3. kg more weight gain in quintile 5 vs. quintile 1, p< 0.0001) and the sum of the less-chlorinated PCBs were positively related to the estimated weight change (3.7. kg more weight gain in quintile 2 vs. quintile 1, non-linear relationship p=0.0015). In contrast, the sum of concentrations of highly-chlorinated PCBs were inversely related to estimated weight change (8.4. kg less weight gain in quintile 5 vs. quintile 1, p< 0.0001).Conclusion: High levels of OC pesticides and the less-chlorinated PCBs at age 70 were associated with a pronounced estimated weight change over the previous 50. years. However, the opposite was seen for highly-chlorinated PCBs. Differences in mode of action, toxicokinetics, non-linear relationships and reverse causation might explain these discrepancies.

Place, publisher, year, edition, pages
2013. Vol. 90, no 3, 998-1004 p.
Keyword [en]
Elderly, Fat mass, Life time weight change, Obesity, Persistent organic pollutants, Life-times, Persistent organic pollutant (POP), Anthropometry, Nutrition, Pesticides, Polychlorinated biphenyls, Organic pollutants, benzene derivative, organic compound, organochlorine pesticide, polybrominated diphenyl ether, polychlorinated biphenyl, body mass, chlorinated hydrocarbon, concentration (composition), elderly population, health impact, organic pollutant, PCB, persistence, pesticide, pollution exposure, toxicology, age, aged, article, female, human, major clinical study, male, mass spectrometry, organic pollution, self report, toxicokinetics, weight change, weight gain, Sweden, Uppsala [Sweden]
National Category
Medical and Health Sciences
URN: urn:nbn:se:uu:diva-192048DOI: 10.1016/j.chemosphere.2012.07.051ISI: 000312978700016OAI: oai:DiVA.org:uu-192048DiVA: diva2:589524
Available from: 2013-01-18 Created: 2013-01-15 Last updated: 2013-02-26Bibliographically approved

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Lind, Monica P.Lind, Lars
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Occupational and Environmental MedicineCardiovascular epidemiology
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