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Ligand biased signaling of opioid agonists forphosphorylation and regulation of μ -opioid receptors
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Neuroscience, Pharmacology. Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Pharmacy, Department of Pharmaceutical Biosciences.
2013 (English)Independent thesis Advanced level (degree of Master (Two Years)), 20 credits / 30 HE creditsStudent thesis
Abstract [en]

Abstract

Ligand biased signaling of opioid agonists for phosphorylation andregulation of μ -opioid receptors

Student: Vida Basti.

Supervisor: Prof Macdonald Christie. Departmement of Neuropharmacology, The University of Sydney.

Examiner: Prof Ingrid Nylander. Departement of Phamacology, University of Uppsala.

Opioid drugs are of great use in the medical practise. The drugs are commonly prescribed formany types of illnesses, mostly in cases of pain management. Although opioids come withmany benefits they are causing a lot of problems as well. The side effects are many andamongst these is tolerance development which may lead to abuse and addiction. Because ofthe fast tolerance development in patients, higher doses up to 10 times the therapeutic doseare being prescribed. This is a major issue in today’s society and must be addressed.Scientists are trying to figure out the mechanism behind tolerance by comparing differenttypes opioid drugs. Some opioids causes tolerance in a much faster rate than others but it isstill uncertain why and what is causing this. Two of the most commonly prescribed opioidsare oxycodone and morphine and so in this rapport these opioids are compared with respectto their capability to cause internalization in neurons. In the experiments a positive control,DAMGO, is being used as well as a negative control. The method being used is an indirectmethod of immunohistochemistry on AtT20 transfected cell culture. The results show thatOxycodone seems to cause no internalization at all in comparison to the control.

Place, publisher, year, edition, pages
2013. , 17 p.
Keyword [en]
oxycodone, morphine, tolerance
National Category
Medical and Health Sciences
Identifiers
URN: urn:nbn:se:uu:diva-192584OAI: oai:DiVA.org:uu-192584DiVA: diva2:600082
External cooperation
University of Sydney, neuropharmacology
Subject / course
Pharmaceutical Pharmacology
Educational program
Master of Science Programme in Pharmacy
Uppsok
Medicine
Supervisors
Examiners
Available from: 2013-01-23 Created: 2013-01-23 Last updated: 2013-02-07Bibliographically approved

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