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A MiniReview of the Use of Hospital-based Databases in Observational Inpatient Studies of Drugs
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Cardiovascular epidemiology.
2013 (English)In: Basic & Clinical Pharmacology & Toxicology, ISSN 1742-7835, E-ISSN 1742-7843, Vol. 112, no 1, 13-18 p.Article, review/survey (Refereed) Published
Abstract [en]

The majority of pharmacoepidemiological data resources are based on data generated in primary health care. Although inpatient data resources have existed since the 1960s, inpatient pharmacoepidemiological studies are relatively scarce. The objectives of this MiniReview were to describe pharmacoepidemiological studies in hospital settings and the underlying databases to provide an overview of research questions addressed by such databases. The studies were retrieved by chain searching. We included pharmacoepidemiological studies in hospital settings containing data on inpatient drug use. Twelve inpatient databases in Asia, the United States and Europe were found. Most databases were automatically collected from claims data or generated from electronic medical records. The contents of the databases varied as well as the potential for linkage with other data sources such as laboratory and outpatient data. Twenty studies were selected and discussed to illustrate the diversity of inpatient pharmacoepidemiological studies. Hospital-based databases had mainly been used for drug utilization studies and research in adverse drug reactions. Five studies within comparative effectiveness were found. The number of pharmacoepidemiological studies in inpatient settings was low compared with studies from primary healthcare settings. These resources may be under-utilized.

Place, publisher, year, edition, pages
2013. Vol. 112, no 1, 13-18 p.
National Category
Medical and Health Sciences
URN: urn:nbn:se:uu:diva-192672DOI: 10.1111/j.1742-7843.2012.00928.xISI: 000312547300005OAI: oai:DiVA.org:uu-192672DiVA: diva2:600429
Available from: 2013-01-24 Created: 2013-01-24 Last updated: 2013-01-24Bibliographically approved

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Larsen, Michael D.
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