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Effect of estrogen and testosterone replacement therapy on cognitive fatigue
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Medicinska och farmaceutiska vetenskapsområdet, centrumbildningar mm, Centrum för klinisk forskning i Sörmland (CKFD).
2013 (English)In: Gynecological Endocrinology, ISSN 0951-3590, E-ISSN 1473-0766, Vol. 29, no 2, 173-176 p.Article in journal (Refereed) Published
Abstract [en]

Both estrogen and testosterone insufficiency has been associated with reduced psychological well-being including fatigue. However, hormonal replacement studies on fatigue are rare. Therefore, we wanted to study the effect of testosterone and estrogen replacement therapy on cognitive fatigue and the relation between sex hormone levels and cognitive fatigue in oophorectomized women. Fifty women with surgically induced menopause (mean age: 54.0±2.9 years) were randomly assigned to treatment with estradiol valerate in combination with testosterone undecanoate or placebo for 24 weeks in a double-blind cross-over study. Neuropsychological tests and questionnaires were used to assess cognitive fatigue and psychological well-being. Cognitive fatigue was significantly associated to poor self-rated health and higher body mass index but not to general psychological well-being or sex hormone levels. Treatment with testosterone + estrogen had no significant effect on cognitive fatigue but the results indicated a curvilinear relation for hormonal levels. The estrogen/testosterone ratio was more related to functions rather than high or low hormone levels per se. We found that cognitive fatigue is frequent in oophorectomized women and negatively associated to self-perceived health and positively associated to BMI. A well-balanced ratio between estrogen and testosterone levels may be important for cognitive fatigue.

Place, publisher, year, edition, pages
2013. Vol. 29, no 2, 173-176 p.
Keyword [en]
Estrogen, Fatigue, Hormone therapy, Oophorectomy, Psychological well-being, Testosterone
National Category
Medical and Health Sciences
URN: urn:nbn:se:uu:diva-191982DOI: 10.3109/09513590.2012.730568ISI: 000313664000023OAI: oai:DiVA.org:uu-191982DiVA: diva2:600711
Available from: 2013-01-25 Created: 2013-01-15 Last updated: 2013-02-19Bibliographically approved

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Möller, Marika Christina
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Centrum för klinisk forskning i Sörmland (CKFD)
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