Regulation of coenzyme Q biosynthesis
1994 (English)In: Molecular Aspects of Medicine, ISSN 0098-2997, E-ISSN 1872-9452, Vol. 15, no Suppl., 37-46 p.Article, review/survey (Refereed) Published
The side-chain moiety of coenzyme Q is synthesized by a trans-prenyltransferase present in microsomes. Condensation of this moiety with the precursor ring takes place in the Golgi system. The enzymes involved, as well as the cytosolic geranylgeranyl-PP synthase, are regulated in an independent fashion. When the size of the farnesyl-PP pool is decreased or increased by employing appropriate inhibitors, the rate of CoQ synthesis is modified accordingly, indicating the dependence of trans-prenyltransferase activity on the level of intracellular substrate concentrations. Administration of peroxisome proliferators elevates CoQ concentrations not only in blood, but also in various tissues. Thus, it may be possible in the future to selectively increase CoQ concentrations in certain organs, without increasing the level of cholesterol.
Place, publisher, year, edition, pages
1994. Vol. 15, no Suppl., 37-46 p.
Medical and Health Sciences
Research subject Biochemistry
IdentifiersURN: urn:nbn:se:uu:diva-193080PubMedID: 7752843OAI: oai:DiVA.org:uu-193080DiVA: diva2:601290