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Evolution of antibiotic resistance at non-lethal drug concentrations.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Biochemistry and Microbiology.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Biochemistry and Microbiology.
2012 (English)In: Drug resistance updates, ISSN 1368-7646, E-ISSN 1532-2084, Vol. 15, no 3, 162-172 p.Article in journal (Refereed) Published
Abstract [en]

Human use of antimicrobials in the clinic, community and agricultural systems has driven selection for resistance in bacteria. Resistance can be selected at antibiotic concentrations that are either lethal or non-lethal, and here we argue that selection and enrichment for antibiotic resistant bacteria is often a consequence of weak, non-lethal selective pressures - caused by low levels of antibiotics - that operates on small differences in relative bacterial fitness. Such conditions may occur during antibiotic therapy or in anthropogenically drug-polluted natural environments. Non-lethal selection increases rates of mutant appearance and promotes enrichment of highly fit mutants and stable mutators.

Place, publisher, year, edition, pages
2012. Vol. 15, no 3, 162-172 p.
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Medical and Health Sciences
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URN: urn:nbn:se:uu:diva-194235DOI: 10.1016/j.drup.2012.03.005PubMedID: 22516308OAI: oai:DiVA.org:uu-194235DiVA: diva2:604513
Available from: 2013-02-11 Created: 2013-02-11 Last updated: 2017-12-06Bibliographically approved

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Andersson, Dan IHughes, Diarmaid

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