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Automated segmentation of free-lying cell nuclei in Pap smears for malignancy-associated change analysis
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2012 (English)In: Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS, 2012, 5372-5375 p.Conference paper, Published paper (Refereed)
Abstract [en]

This paper presents an automated algorithm for robustly detecting and segmenting free-lying cell nuclei in bright-field microscope images of Pap smears. This is an essential initial step in the development of an automated screening system for cervical cancer based on malignancy associated change (MAC) analysis. The proposed segmentation algorithm makes use of gray-scale annular closings to identify free-lying nuclei-like objects together with marker-based watershed segmentation to accurately delineate the nuclear boundaries. The algorithm also employs artifact rejection based on size, shape, and granularity to ensure only the nuclei of intermediate squamous epithelial cells are retained. An evaluation of the performance of the algorithm relative to expert manual segmentation of 33 fields-of-view from 11 Pap smear slides is also presented. The results show that the sensitivity and specificity of nucleus detection is 94.71% and 85.30% respectively, and that the accuracy of segmentation, measured using the Dice coefficient, of the detected nuclei is 97.30±1.3%.

Place, publisher, year, edition, pages
2012. 5372-5375 p.
Series
Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS, ISSN 1557-170X
National Category
Medical Image Processing
Identifiers
URN: urn:nbn:se:uu:diva-193893DOI: 10.1109/EMBC.2012.6347208ISBN: 978-1-4244-4119-8 (print)OAI: oai:DiVA.org:uu-193893DiVA: diva2:604914
Conference
34th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS 2012, 28 August 2012 through 1 September 2012, San Diego, CA
Available from: 2013-02-12 Created: 2013-02-06 Last updated: 2017-02-08Bibliographically approved

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Malm, PatrikBengtsson, Ewert

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