uu.seUppsala University Publications
Change search
ReferencesLink to record
Permanent link

Direct link
Premedication for intubation with morphine causes prolonged depression of electrocortical background activity in preterm infants
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Women's and Children's Health, Pediatrics.
Show others and affiliations
2013 (English)In: Pediatric Research, ISSN 0031-3998, E-ISSN 1530-0447, Vol. 73, no 1, 87-94 p.Article in journal (Refereed) Published
Abstract [en]

BACKGROUND: Sedative and analgesic medications are used in critically ill newborns, but little is known about their effects on electrocortical activity in preterm infants. We hypothesized that morphine might induce prolonged neurodepression, independent of blood pressure, as compared with rapid sequence induction/intubation (RSI). METHODS: Of 34 infants enrolled in a randomized controlled trial (RCT) comparing RSI (including thiopental 2-3 mg/kg and remifentantil 1 mcg/kg) with morphine (0.3 mg/kg) as premedication for intubation, 28 infants (n = 14 + 14; median gestational age 26.1 wk and postnatal age 138 h) had continuous two-channel amplitude-integrated electroencephalogram (aEEG/EEG) and blood pressure monitoring during 24h after the intubation. Thirteen infants not receiving any additional medication constituted the primary study group. Visual and quantitative analyses of aEEG/EEG and blood pressure were performed in 3-h epochs. RESULTS: RSI was associated with aEEG/EEG depression lasting <3 h. Morphine premedication resulted in aEEG/EEG depression with more discontinuous background and less developed cyclicity for 24h, and during the first 9h, interburst intervals (IBI) were significantly increased as compared with those of RSI treatment. The difference was not related to blood pressure. CONCLUSION: Premedication with morphine is associated with prolonged aEEG/EEG depression independent of blood pressure changes and may not be optimal for short procedures.

Place, publisher, year, edition, pages
2013. Vol. 73, no 1, 87-94 p.
National Category
Medical and Health Sciences
URN: urn:nbn:se:uu:diva-194217DOI: 10.1038/pr.2012.153ISI: 000313307900014OAI: oai:DiVA.org:uu-194217DiVA: diva2:604967
Available from: 2013-02-12 Created: 2013-02-11 Last updated: 2013-02-12Bibliographically approved

Open Access in DiVA

No full text

Other links

Publisher's full text

Search in DiVA

By author/editor
Wikström, SverreHellström-Westas, Lena
By organisation
In the same journal
Pediatric Research
Medical and Health Sciences

Search outside of DiVA

GoogleGoogle Scholar

Altmetric score

Total: 286 hits
ReferencesLink to record
Permanent link

Direct link