Excessive dietary intake of vitamin A is associated with reduced bone mineral density and increased risk for hip fracture
1998 (English)In: Annals of Internal Medicine, ISSN 0003-4819, Vol. 129, no 10, 770-8 p.Article in journal (Refereed) Published
BACKGROUND: The highest incidence of osteoporotic fractures is found in northern Europe, where dietary intake of vitamin A (retinol) is unusually high. In animals, the most common adverse effect of toxic doses of retinol is spontaneous fracture. OBJECTIVE: To investigate whether excessive dietary intake of vitamin A is associated with decreased bone mineral density and increased risk for hip fracture. DESIGN: A cross-sectional study and a nested case-control study. SETTING: Two counties in central Sweden. PARTICIPANTS: For the cross-sectional study, 175 women 28 to 74 years of age were randomly selected. For the nested case-control study, 247 women who had a first hip fracture within 2 to 64 months after enrollment and 873 age-matched controls were selected from a mammography study cohort of 66,651 women 40 to 76 years of age. MEASUREMENTS: Retinol intake was estimated from dietary records and a food-frequency questionnaire. Bone mineral density was measured with dual-energy x-ray absorptiometry. Hip fracture was identified by using hospital discharge records and was confirmed by record review. RESULTS: In multivariate analysis, retinol intake was negatively associated with bone mineral density. For every 1-mg increase in daily intake of retinol, risk for hip fracture increased by 68% (95% CI, 18% to 140%; P for trend, 0.006). For intake greater than 1.5 mg/d compared with intake less than 0.5 mg/d, bone mineral density was reduced by 10% at the femoral neck (P = 0.05), 14% at the lumbar spine (P = 0.001), and 6% for the total body (P = 0.009) and risk for hip fracture was doubled (odds ratio, 2.1 [CI, 1.1 to 4.0]). CONCLUSION: High dietary intake of retinol seems to be associated with osteoporosis.
Place, publisher, year, edition, pages
1998. Vol. 129, no 10, 770-8 p.
hip fracture, bone density, vitamin A, hypervitaminosis A, osteoporosis, green leafy vegetables, retinoic acid, breast cancer, A status, resorption Norway, 9-CIS
Medical and Health Sciences
IdentifiersURN: urn:nbn:se:uu:diva-32711PubMedID: 9841582OAI: oai:DiVA.org:uu-32711DiVA: diva2:60609
Addresses: Melhus H, Univ Uppsala Hosp, Dept Internal Med, S-75185 Uppsala, Sweden. Univ Uppsala Hosp, Dept Internal Med, S-75185 Uppsala, Sweden. Karolinska Inst, Dept Med Epidemiol, S-17177 Stockholm, Sweden. Univ Uppsala Hosp, Dept Surg, S-75185 Uppsal2008-10-172008-10-172009-10-29Bibliographically approved