uu.seUppsala University Publications
Change search
ReferencesLink to record
Permanent link

Direct link
Marked host specificity and lack of phylogeographic population structure of Campylobacter jejuni in wild birds
Show others and affiliations
2013 (English)In: Molecular Ecology, ISSN 0962-1083, E-ISSN 1365-294X, Vol. 22, no 5, 1463-1472 p.Article in journal (Refereed) Published
Abstract [en]

Zoonotic pathogens often infect several animal species, and gene flow among populations infecting different host species may affect the biological traits of the pathogen including host specificity, transmissibility and virulence. The bacterium Campylobacter jejuni is a widespread zoonotic multihost pathogen, which frequently causes gastroenteritis in humans. Poultry products are important transmission vehicles to humans, but the bacterium is common in other domestic and wild animals, particularly birds, which are a potential infection source. Population genetic studies of C. jejuni have mainly investigated isolates from humans and domestic animals, so to assess C. jejuni population structure more broadly and investigate host adaptation, 928 wild bird isolates from Europe and Australia were genotyped by multilocus sequencing and compared to the genotypes recovered from 1366 domestic animal and human isolates. Campylobacter jejuni populations from different wild bird species were distinct from each other and from those from domestic animals and humans, and the host species of wild bird was the major determinant of C. jejuni genotype, while geographic origin was of little importance. By comparison, C. jejuni differentiation was restricted between more phylogenetically diverse farm animals, indicating that domesticated animals may represent a novel niche for C. jejuni and thereby driving the evolution of those bacteria as they exploit this niche. Human disease is dominated by isolates from this novel domesticated animal niche.

Place, publisher, year, edition, pages
2013. Vol. 22, no 5, 1463-1472 p.
National Category
Medical and Health Sciences
URN: urn:nbn:se:uu:diva-194956DOI: 10.1111/mec.12144ISI: 000315414700020PubMedID: 23356487OAI: oai:DiVA.org:uu-194956DiVA: diva2:606671
Available from: 2013-02-20 Created: 2013-02-20 Last updated: 2013-04-02Bibliographically approved

Open Access in DiVA

No full text

Other links

Publisher's full textPubMed

Search in DiVA

By author/editor
Olsen, Björn
By organisation
Infectious Diseases
In the same journal
Molecular Ecology
Medical and Health Sciences

Search outside of DiVA

GoogleGoogle Scholar
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

Altmetric score

Total: 263 hits
ReferencesLink to record
Permanent link

Direct link