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Endotoxin-induced and vaccine-induced systemic inflammation both impair endothelium-dependent vasodilation, but not pulse wave reflection
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Cardiovascular epidemiology.
2012 (English)In: Vascular health and risk management, ISSN 1178-2048, Vol. 8, 447-453 p.Article in journal (Refereed) Published
Abstract [en]

Inflammation induced by either endotoxin or vaccination has previously been shown to impair endothelium-dependent vasodilation (EDV) in healthy young individuals. However, the vascular effects of these two mechanisms of inducing inflammation have not been compared in the same individuals. Twelve young healthy males were studied at the same time of the day on three occasions in a random order; on one occasion 4 hours following an endotoxin injection (Escherichia coli endotoxin, 20 IU/kg), on another occasion 8 hours following vaccination against Salmonella typhi, and on a third occasion 4 hours following a saline control injection. EDV and endothelium-independent vasodilation (EIDV) were evaluated by local infusions of acetylcholine and sodium nitroprusside in the brachial artery, and forearm blood flow was measured with venous occlusion plethysmography. The augmentation index was determined by pulse wave analysis as an index of pulse wave reflection. Both endotoxin and vaccination impaired EDV to a similar degree compared with the saline control (P = 0.005 and P = 0.014, respectively). EIDV was not significantly affected by inflammation. Endotoxin, but not vaccination, increased body temperature and circulating levels of intracellular adhesion molecule-1 and interleukin-6. Augmentation index was not affected by the interventions. Despite the fact that endotoxin induced a more pronounced degree of inflammation than vaccination, both inflammatory challenges impaired EDV to a similar degree, supporting the view that different inflammatory stimuli could induce harmful effects on the vasculature.

Place, publisher, year, edition, pages
2012. Vol. 8, 447-453 p.
Keyword [en]
acetylcholine, autacoid, biological marker, endotoxin, endotoxin, Escherichia coli, IL6 protein, human, intercellular adhesion molecule 1, interleukin 6, nitroprusside sodium, salmonellosis vaccine, vasodilator agent, adult, arterial stiffness, article, blood, blood flow, body temperature, brachial artery, chemically induced disorder, clinical trial, comparative study, controlled clinical trial, controlled study, crossover procedure, drug effect, forearm, human, immunology, inflammation, intraarterial drug administration, male, pathophysiology, plethysmography, pulse wave, randomized controlled trial, Salmonella typhi, time, vascularization, vasodilatation, Biological Markers, Cross-Over Studies, Endotoxins, Humans, Inflammation Mediators, Infusions, Intra-Arterial, Intercellular Adhesion Molecule-1, Interleukin-6, Nitroprusside, Pulse Wave Analysis, Regional Blood Flow, Salmonella Vaccines, Time Factors, Vascular Stiffness, Vasodilation, Vasodilator Agents, Young Adult
National Category
Medical and Health Sciences
URN: urn:nbn:se:uu:diva-195185DOI: 10.2147/VHRM.S19161PubMedID: 22866006OAI: oai:DiVA.org:uu-195185DiVA: diva2:607300
Available from: 2013-02-22 Created: 2013-02-21 Last updated: 2013-02-22Bibliographically approved

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