Triazolopyrimidinones as gamma-secretase modulators: structure-activity relationship, modulator profile, and in vivo profiling
2013 (English)In: MedChemComm, ISSN 2040-2503, E-ISSN 2040-2511, Vol. 4, no 2, 422-431 p.Article in journal (Refereed) Published
The structure-activity relationship for a series of potent g-secretase modulators based on the 6,7-dihydro4H-[1,2,4]triazolo[1,5-a]pyrimidin-5-one scaffold is described. Furthermore, we report details regarding the modulator profile on A beta processing, as well as in vivo efficacy, for the optimized compounds.
Place, publisher, year, edition, pages
2013. Vol. 4, no 2, 422-431 p.
Medical and Health Sciences
IdentifiersURN: urn:nbn:se:uu:diva-196029DOI: 10.1039/c2md20312jISI: 000314311600019OAI: oai:DiVA.org:uu-196029DiVA: diva2:609082