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Triazolopyrimidinones as gamma-secretase modulators: structure-activity relationship, modulator profile, and in vivo profiling
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2013 (English)In: MedChemComm, ISSN 2040-2503, E-ISSN 2040-2511, Vol. 4, no 2, 422-431 p.Article in journal (Refereed) Published
Abstract [en]

The structure-activity relationship for a series of potent g-secretase modulators based on the 6,7-dihydro4H-[1,2,4]triazolo[1,5-a]pyrimidin-5-one scaffold is described. Furthermore, we report details regarding the modulator profile on A beta processing, as well as in vivo efficacy, for the optimized compounds.

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2013. Vol. 4, no 2, 422-431 p.
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Medical and Health Sciences
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URN: urn:nbn:se:uu:diva-196029DOI: 10.1039/c2md20312jISI: 000314311600019OAI: oai:DiVA.org:uu-196029DiVA: diva2:609082
Available from: 2013-03-04 Created: 2013-03-04 Last updated: 2017-12-06

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Yngve, UlrikaArvidsson, Per I.

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