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Consequences of Morphology on Molecularly Imprinted Polymer-Ligand Recognition
Uppsala University, Disciplinary Domain of Science and Technology, Chemistry, Department of Chemistry - BMC.
2013 (English)In: International Journal of Molecular Sciences, ISSN 1422-0067, Vol. 14, no 1, 1207-1217 p.Article in journal (Refereed) Published
Abstract [en]

The relationship between molecularly imprinted polymer (MIP) morphology and template-rebinding over a series of warfarin-imprinted methacrylic acid co(ethylene dimethacrylate) polymers has been explored. Detailed investigations of the nature of template recognition revealed that an optimal template binding was obtained with polymers possessing a narrow population of pores (similar to 3-4 nm) in the mesopore size range. Importantly, the warfarin-polymer rebinding analyses suggest strategies for regulating ligand binding capacity and specificity through variation of the degree of cross-linking, where polymers prepared with a lower degree of cross-linking afford higher capacity though non-specific in character. In contrast, the co-existence of specific and non-specific binding was found in conjunction with higher degrees of cross-linking and resultant meso-and macropore size distributions.

Place, publisher, year, edition, pages
2013. Vol. 14, no 1, 1207-1217 p.
Keyword [en]
molecularly imprinted polymer, MIP, morphology, BET, surface area, warfarin
National Category
Natural Sciences
URN: urn:nbn:se:uu:diva-196082DOI: 10.3390/ijms14011207ISI: 000314048800071OAI: oai:DiVA.org:uu-196082DiVA: diva2:609271
Available from: 2013-03-05 Created: 2013-03-04 Last updated: 2013-03-05Bibliographically approved

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