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Acute sleep deprivation increases portion size and affects food choice in young men
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Neuroscience, Functional Pharmacology.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Neuroscience, Functional Pharmacology.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Neuroscience, Functional Pharmacology.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Neuroscience, Functional Pharmacology.
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2013 (English)In: Psychoneuroendocrinology, ISSN 0306-4530, E-ISSN 1873-3360, Vol. 38, no 9, 1668-1674 p.Article in journal (Refereed) Published
Abstract [en]

Acute sleep loss increases food intake in adults. However, little is known about the influence of acute sleep loss on portion size choice, and whether this depends on both hunger state and the type of food (snack or meal item) offered to an individual. The aim of the current study was to compare portion size choice after a night of sleep and a period of nocturnal wakefulness (a condition experienced by night-shift workers, e.g. physicians and nurses). Sixteen men (age: 23 ± 0.9 years, BMI: 23.6 ± 0.6 kg/m2) participated in a randomized within-subject design with two conditions, 8-h of sleep and total sleep deprivation (TSD). In the morning following sleep interventions, portion size, comprising meal and snack items, was measured using a computer-based task, in both fasted and sated state. In addition, hunger as well as plasma levels of ghrelin were measured. In the morning after TSD, subjects had increased plasma ghrelin levels (13%, p = 0.04), and chose larger portions (14%, p = 0.02), irrespective of the type of food, as compared to the sleep condition. Self-reported hunger was also enhanced (p < 0.01). Following breakfast, sleep-deprived subjects chose larger portions of snacks (16%, p = 0.02), whereas the selection of meal items did not differ between the sleep interventions (6%, p = 0.13). Our results suggest that overeating in the morning after sleep loss is driven by both homeostatic and hedonic factors. Further, they show that portion size choice after sleep loss depend on both an individual's hunger status, and the type of food offered.

Place, publisher, year, edition, pages
2013. Vol. 38, no 9, 1668-1674 p.
National Category
Medical and Health Sciences
Identifiers
URN: urn:nbn:se:uu:diva-196214DOI: 10.1016/j.psyneuen.2013.01.012ISI: 000325188300021PubMedID: 23428257OAI: oai:DiVA.org:uu-196214DiVA: diva2:609456
Note

De två sista författarna delar sistaförfattarskapet.

Available from: 2013-03-05 Created: 2013-03-05 Last updated: 2017-12-06Bibliographically approved
In thesis
1. Genome wide methylation analysis and obesity related traits
Open this publication in new window or tab >>Genome wide methylation analysis and obesity related traits
2015 (English)Doctoral thesis, comprehensive summary (Other academic)
Abstract [en]

The most studied form of epigenetics is DNA methylation and several studies have investigated the link between the methylome and body weight. In paper I we analyzed the methylation profile of whole blood in 46 subjects measured with Illumina 27K chip. We provide evidence that obesity influences age driven epigenetic changes. These identified markers may prove to be valuable biomarkers for the understanding of the molecular basis of aging, obesity and associated diseases. In paper II we studied the effect of bariatric surgery, and subsequent weight loss, on methylation and relating this to normal weight controls. In paper II we found 115 promoters had altered methylation after surgery. Among these promoters, an enrichment for genes involved in metabolic processes was found (n=36, p<0.05). In addition, these 51 promoters was more similar after surgery to that of normal-weight controls, than it had been at baseline (p<0.0001). One of the major comorbidities of severe obesity is obstructive sleep apnea and lack of sleep is highly correlated with obesity. Paper III shows how acute sleep deprivation increases portion size and affects food choice in 16 young men. In paper VI, whole genome DNA methylation profiles of whole blood was assessed following both conditions by the Illumina 450K methylation in the same trial as in paper III. This paper shows how sleep deprivation affects DNA methylation profiles of whole blood in a manner both dependent and independent on monocyte subpopulations. Hypothesis free genome wide analysis revealed differential methylation in ING5, a gene previously known to be differentially expressed in sleep deprivation. 

Place, publisher, year, edition, pages
Uppsala: Acta Universitatis Upsaliensis, 2015. 40 p.
Series
Digital Comprehensive Summaries of Uppsala Dissertations from the Faculty of Medicine, ISSN 1651-6206 ; 1101
National Category
Neurosciences
Identifiers
urn:nbn:se:uu:diva-248685 (URN)978-91-554-9236-6 (ISBN)
Public defence
2015-06-05, BMC C2:301, Husargatan 3, Uppsala, 13:00 (English)
Opponent
Supervisors
Available from: 2015-05-12 Created: 2015-04-07 Last updated: 2015-07-07Bibliographically approved

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Hogenkamp, Pleunie SNilsson, EmilCedernaes, JonathanRångtell, Frida HBroman, Jan-ErikBenedict, ChristianSchiöth, Helgi B

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