uu.seUppsala University Publications
Change search
ReferencesLink to record
Permanent link

Direct link
Advances in PET Imaging of P-Glycoprotein Function at the Blood-Brain Barrier.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Public Health and Caring Sciences, Geriatrics.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Pharmacy, Department of Medicinal Chemistry, Preclinical PET Platform.ORCID iD: 0000-0003-0241-092X
2013 (English)In: ACS Chemical Neuroscience, ISSN 1948-7193, Vol. 4, no 2, 225-237 p.Article, review/survey (Refereed) Published
Abstract [en]

Efflux transporter P-glycoprotein (P-gp) at the blood-brain barrier (BBB) restricts substrate compounds from entering the brain and may thus contribute to pharmacoresistance observed in patient groups with refractory epilepsy and HIV. Altered P-gp function has also been implicated in neurodegenerative diseases such as Alzheimer's and Parkinson's disease. Positron emission tomography (PET), a molecular imaging modality, has become a promising method to study the role of P-gp at the BBB. The first PET study of P-gp function was conducted in 1998, and during the past 15 years two main categories of P-gp PET tracers have been investigated: tracers that are substrates of P-gp efflux and tracers that are inhibitors of P-gp function. PET, as a noninvasive imaging technique, allows translational research. Examples of this are preclinical investigations of P-gp function before and after administering P-gp modulating drugs, investigations in various animal and disease models, and clinical investigations regarding disease and aging. The objective of the present review is to give an overview of available PET radiotracers for studies of P-gp and to discuss how such studies can be designed. Further, the review summarizes results from PET studies of P-gp function in different central nervous system disorders.

Place, publisher, year, edition, pages
2013. Vol. 4, no 2, 225-237 p.
National Category
Basic Medicine
URN: urn:nbn:se:uu:diva-196266DOI: 10.1021/cn3001729ISI: 000315326000003PubMedID: 23421673OAI: oai:DiVA.org:uu-196266DiVA: diva2:609599
Available from: 2013-03-06 Created: 2013-03-06 Last updated: 2013-08-13Bibliographically approved

Open Access in DiVA

No full text

Other links

Publisher's full textPubMed

Search in DiVA

By author/editor
Syvänen, StinaEriksson, Jonas
By organisation
GeriatricsPreclinical PET Platform
In the same journal
ACS Chemical Neuroscience
Basic Medicine

Search outside of DiVA

GoogleGoogle Scholar
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

Altmetric score

Total: 226 hits
ReferencesLink to record
Permanent link

Direct link