Advances in PET Imaging of P-Glycoprotein Function at the Blood-Brain Barrier.
2013 (English)In: ACS Chemical Neuroscience, ISSN 1948-7193, Vol. 4, no 2, 225-237 p.Article, review/survey (Refereed) Published
Efflux transporter P-glycoprotein (P-gp) at the blood-brain barrier (BBB) restricts substrate compounds from entering the brain and may thus contribute to pharmacoresistance observed in patient groups with refractory epilepsy and HIV. Altered P-gp function has also been implicated in neurodegenerative diseases such as Alzheimer's and Parkinson's disease. Positron emission tomography (PET), a molecular imaging modality, has become a promising method to study the role of P-gp at the BBB. The first PET study of P-gp function was conducted in 1998, and during the past 15 years two main categories of P-gp PET tracers have been investigated: tracers that are substrates of P-gp efflux and tracers that are inhibitors of P-gp function. PET, as a noninvasive imaging technique, allows translational research. Examples of this are preclinical investigations of P-gp function before and after administering P-gp modulating drugs, investigations in various animal and disease models, and clinical investigations regarding disease and aging. The objective of the present review is to give an overview of available PET radiotracers for studies of P-gp and to discuss how such studies can be designed. Further, the review summarizes results from PET studies of P-gp function in different central nervous system disorders.
Place, publisher, year, edition, pages
2013. Vol. 4, no 2, 225-237 p.
IdentifiersURN: urn:nbn:se:uu:diva-196266DOI: 10.1021/cn3001729ISI: 000315326000003PubMedID: 23421673OAI: oai:DiVA.org:uu-196266DiVA: diva2:609599