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Tissue Factor non-coagulant signalling - molecular mechanisms and biological consequences with focus on cell migration and apoptosis
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Coagulation and inflammation science.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Coagulation and inflammation science.
2013 (English)In: Journal of Thrombosis and Haemostasis, ISSN 1538-7933, E-ISSN 1538-7836, Vol. 11, no 5, 817-825 p.Article in journal (Refereed) Published
Abstract [en]

Tissue factor (TF), a transmembrane glycoprotein, is the main initiator of the blood coagulation cascade. TF is also recognized as a true signalling receptor. There is accumulating evidence that the downstream signalling events by the TF-complexes are transduced by several mechanisms including; activation of the protease activated receptors (PAR)-1 and -2 and the PARs-dependent pathways, via the TF cytoplasmic domain and by transactivation of receptor tyrosine kinases. Triggering of signalling cascades such as the mitogen-activated protein kinase (MAPK) and PI3kinase/AKT pathways couples TF to a multitude of functions within the cell, such as proliferation, cell migration and survival. Thus, TF has a Janus face; on the one side vital life upholding functions and on the other harmful effects, exemplified in inflammation, the acute coronary syndromes and cancer. TF mediates a broad spectrum of signalling mechanisms. Learning more about these different mechanisms/pathways will lead to new treatment strategies, ultimately personalized.

Place, publisher, year, edition, pages
2013. Vol. 11, no 5, 817-825 p.
National Category
Medical and Health Sciences Basic Medicine
Identifiers
URN: urn:nbn:se:uu:diva-196284DOI: 10.1111/jth.12156ISI: 000319011900004PubMedID: 23384027OAI: oai:DiVA.org:uu-196284DiVA: diva2:609664
Available from: 2013-03-06 Created: 2013-03-06 Last updated: 2017-12-06Bibliographically approved

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Åberg, MikaelSiegbahn, Agneta

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