Tissue Factor non-coagulant signalling - molecular mechanisms and biological consequences with focus on cell migration and apoptosis
2013 (English)In: Journal of Thrombosis and Haemostasis, ISSN 1538-7933, E-ISSN 1538-7836, Vol. 11, no 5, 817-825 p.Article in journal (Refereed) Published
Tissue factor (TF), a transmembrane glycoprotein, is the main initiator of the blood coagulation cascade. TF is also recognized as a true signalling receptor. There is accumulating evidence that the downstream signalling events by the TF-complexes are transduced by several mechanisms including; activation of the protease activated receptors (PAR)-1 and -2 and the PARs-dependent pathways, via the TF cytoplasmic domain and by transactivation of receptor tyrosine kinases. Triggering of signalling cascades such as the mitogen-activated protein kinase (MAPK) and PI3kinase/AKT pathways couples TF to a multitude of functions within the cell, such as proliferation, cell migration and survival. Thus, TF has a Janus face; on the one side vital life upholding functions and on the other harmful effects, exemplified in inflammation, the acute coronary syndromes and cancer. TF mediates a broad spectrum of signalling mechanisms. Learning more about these different mechanisms/pathways will lead to new treatment strategies, ultimately personalized.
Place, publisher, year, edition, pages
2013. Vol. 11, no 5, 817-825 p.
Medical and Health Sciences Basic Medicine
IdentifiersURN: urn:nbn:se:uu:diva-196284DOI: 10.1111/jth.12156ISI: 000319011900004PubMedID: 23384027OAI: oai:DiVA.org:uu-196284DiVA: diva2:609664