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From archaeon to eukaryote: the evolutionary dark ages of the eukaryotic cell
Uppsala University, Disciplinary Domain of Science and Technology, Biology, Department of Cell and Molecular Biology, Molecular Evolution. Uppsala University, Science for Life Laboratory, SciLifeLab.
Uppsala University, Disciplinary Domain of Science and Technology, Biology, Department of Cell and Molecular Biology, Molecular Evolution. Uppsala University, Science for Life Laboratory, SciLifeLab.
2013 (English)In: Biochemical Society Transactions, ISSN 0300-5127, E-ISSN 1470-8752, Vol. 41, 451-457 p.Article in journal (Refereed) Published
Abstract [en]

The evolutionary origin of the eukaryotic cell represents an enigmatic, yet largely incomplete, puzzle. Several mutually incompatible scenarios have been proposed to explain how the eukaryotic domain of life could have emerged. To date, convincing evidence for these scenarios in the form of intermediate stages of the proposed eukaryogenesis trajectories is lacking, presenting the emergence of the complex features of the eukaryotic cell as an evolutionary deus ex machina. However, recent advances in the field of phylogenomics have started to lend support for a model that places a cellular fusion event at the basis of the origin of eukaryotes (symbiogenesis), involving the merger of an as yet unknown archaeal lineage that most probably belongs to the recently proposed 'TACK superphylum' (comprising Thaumarchaeota, Aigarchaeota, Crenarchaeota and Korarchaeota) with an alphaproteobacterium (the protomitochondrion). Interestingly, an increasing number of so-called ESPs (eukaryotic signature proteins) is being discovered in recently sequenced archaeal genomes, indicating that the archaeal ancestor of the eukaryotic cell might have been more eukaryotic in nature than presumed previously, and might, for example, have comprised primitive phagocytotic capabilities. In the present paper, we review the evolutionary transition from archaeon to eukaryote, and propose a new model for the emergence of the eukaryotic cell, the 'PhAT (phagocytosing archaeon theory)', which explains the emergence of the cellular and genomic features of eukaryotes in the light of a transiently complex phagocytosing archaeon.

Place, publisher, year, edition, pages
2013. Vol. 41, 451-457 p.
Keyword [en]
Archaea, eukaryogeneois, horizontal gene transfer (HGT), last eukaryotic common ancestor (LECA), phagocytosing archaeon theory (PhAT)
National Category
Natural Sciences
Identifiers
URN: urn:nbn:se:uu:diva-196542DOI: 10.1042/BST20120292ISI: 000314222900076OAI: oai:DiVA.org:uu-196542DiVA: diva2:610826
Available from: 2013-03-13 Created: 2013-03-11 Last updated: 2017-12-06Bibliographically approved

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Martijn, JoranEttema, Thijs J. G.

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