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Measurements of total and regional body composition in preschool children: a comparison of MRI, DXA and anthropometric data
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Radiology, Oncology and Radiation Science, Radiology.
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2013 (English)In: Obesity, ISSN 1930-7381, Vol. 21, no 5, 1018-1024 p.Article in journal (Refereed) Published
Abstract [en]

The presence of adipose tissue in the abdominal area in particular is associated with unfavourable metabolic changes. Furthermore, there are clear sex differences in the distribution of visceral adipose tissue (VAT) and subcutaneous adipose tissue (SAT) in adults, with males having more VAT and less SAT than females. The present study assessed whether these differences between the sexes were already present in preschool children. It also evaluated which measures of body composition were most appropriate for assessing abdominal obesity in this age group. One-hundred and five children (57 boys, 48 girls) participated in the study. Body composition was measured using dual-energy X-ray absorptionetry (DXA). Weight, height and waist circumference (WC) were also recorded. Magnetic resonance imaging (MRI) of the entire abdomen using sixteen 10 mm thick T1-weighted slices was performed in a subgroup of 48 children (30 boys, 18 girls); SAT and VAT volumes were measured using semi-automated segmentation.

Boys had significantly more VAT than girls (0.17 versus 0.10 L, p<0.001). Results showed that VAT correlated significantly with all measurements of anthropometry (p<0.01) after adjusting for SAT and for total fat mass measured with DXA. The mean limits of agreement between DXA and MRI regarding truncal FM were calculated to -11.4 (range -17.8 to -3.6), using a Bland-Altman plot.

In conclusion, sex differences in adipose tissue distribution are apparent at an early age. MRI is the best method with which to study abdominal fat distribution in young children.

Place, publisher, year, edition, pages
2013. Vol. 21, no 5, 1018-1024 p.
National Category
Basic Medicine
URN: urn:nbn:se:uu:diva-196727DOI: 10.1002/oby.20205ISI: 000322088300024OAI: oai:DiVA.org:uu-196727DiVA: diva2:610874
Available from: 2013-03-13 Created: 2013-03-13 Last updated: 2013-09-09Bibliographically approved

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