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Rat brain capillary endothelial cells express functional PDGF B-type receptors
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Medicinska och farmaceutiska vetenskapsområdet, centrumbildningar mm, Ludwig Institute for Cancer Research.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Medicinska och farmaceutiska vetenskapsområdet, centrumbildningar mm, Ludwig Institute for Cancer Research.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Medicinska och farmaceutiska vetenskapsområdet, centrumbildningar mm, Ludwig Institute for Cancer Research.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Medicinska och farmaceutiska vetenskapsområdet, centrumbildningar mm, Ludwig Institute for Cancer Research.
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1989 (English)In: Growth Factors, ISSN 0897-7194, E-ISSN 1029-2292, Vol. 2, no 1, 1-8 p.Article in journal (Refereed) Published
Abstract [en]

Immunohistochemical staining revealed the presence of platelet-derived growth factor (PDGF) B-type receptors on capillaries of normal rat brain. Furthermore, capillary endothelial cells isolated from rat brain and grown in tissue culture bound [125I]PDGF-BB but not [125I]PDGF-AA, suggesting that they expressed B-type, but not A-type, PDGF receptors. PDGF-BB and PDGF-AB, but not PDGF-AA, also stimulated incorporation of [3H]thymidine into these cells. Thus, rat brain capillary endothelial cells have functional B-type receptors, and thereby differ from endothelial cells derived from large blood vessels, that do not express PDGF receptors. Our data suggest a possible role for PDGF-BB as an angiogenic factor.

Place, publisher, year, edition, pages
1989. Vol. 2, no 1, 1-8 p.
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Medical and Health Sciences
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URN: urn:nbn:se:uu:diva-197022PubMedID: 2561393OAI: oai:DiVA.org:uu-197022DiVA: diva2:611506
Available from: 2013-03-16 Created: 2013-03-16 Last updated: 2017-12-06Bibliographically approved

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Smits, AnjaHeldin, Carl-HenrikWestermark, Bengt

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