Rat brain capillary endothelial cells express functional PDGF B-type receptors
1989 (English)In: Growth Factors, ISSN 0897-7194, Vol. 2, no 1, 1-8 p.Article in journal (Refereed) Published
Immunohistochemical staining revealed the presence of platelet-derived growth factor (PDGF) B-type receptors on capillaries of normal rat brain. Furthermore, capillary endothelial cells isolated from rat brain and grown in tissue culture bound [125I]PDGF-BB but not [125I]PDGF-AA, suggesting that they expressed B-type, but not A-type, PDGF receptors. PDGF-BB and PDGF-AB, but not PDGF-AA, also stimulated incorporation of [3H]thymidine into these cells. Thus, rat brain capillary endothelial cells have functional B-type receptors, and thereby differ from endothelial cells derived from large blood vessels, that do not express PDGF receptors. Our data suggest a possible role for PDGF-BB as an angiogenic factor.
Place, publisher, year, edition, pages
1989. Vol. 2, no 1, 1-8 p.
Medical and Health Sciences
IdentifiersURN: urn:nbn:se:uu:diva-197022PubMedID: 2561393OAI: oai:DiVA.org:uu-197022DiVA: diva2:611506