uu.seUppsala University Publications
Change search
ReferencesLink to record
Permanent link

Direct link
Virotherapy of Neuroendocrine Tumors
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Immunology, Genetics and Pathology. (Rudbeck Lab)
2013 (English)In: Neuroendocrinology, ISSN 0028-3835, E-ISSN 1423-0194, Vol. 97, no 1, 26-34 p.Article in journal (Refereed) Published
Abstract [en]

Most patients with small intestinal neuroendocrine tumors (SI-NETs), also referred to as midgut carcinoids, present with systemic disease at the time of diagnosis with metastases primarily found in regional lymph nodes and the liver. Curative treatment is not available for these patients and there is a need for novel and specific therapies. Engineered oncolytic viruses may meet the need and play an important role in the future management of SI-NET liver metastases. This review focuses on adenovirus as the oncolytic anti-cancer agent and its potential curative role for SI-NET liver metastases, but it also summarizes the use of oncolytic viruses for NETs in general. It discusses how specific features of neuroendocrine cell biology can be used to engineer viruses to become selective for infection of NET cells and/or replication within NET cells. In addition, it points out the advantages and shortcomings of using replicating viruses in the treatment of cancer and addresses research fields that can increase the efficacy of virus-based therapy.

Place, publisher, year, edition, pages
2013. Vol. 97, no 1, 26-34 p.
Keyword [en]
Oncolytic virus, Adenovirus, Promoter, MicroRNA, Fiber, Hexon, Neuroendocrine tumors
National Category
Medical and Health Sciences
URN: urn:nbn:se:uu:diva-197143DOI: 10.1159/000336084ISI: 000315005700004OAI: oai:DiVA.org:uu-197143DiVA: diva2:611817
Available from: 2013-03-18 Created: 2013-03-18 Last updated: 2013-03-18Bibliographically approved

Open Access in DiVA

No full text

Other links

Publisher's full text
By organisation
Department of Immunology, Genetics and Pathology
In the same journal
Medical and Health Sciences

Search outside of DiVA

GoogleGoogle Scholar
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

Altmetric score

Total: 167 hits
ReferencesLink to record
Permanent link

Direct link