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Capillary microsampling in the regulatory environment: validation and use of bioanalytical capillary microsampling methods
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Pharmacy, Department of Medicinal Chemistry, Analytical Pharmaceutical Chemistry.
2013 (English)In: Bioanalysis, ISSN 1757-6180, Vol. 5, no 6, 731-738 p.Article in journal (Refereed) Published
Abstract [en]

Capillary microsampling (CMS) has recently been introduced as a response to the demands for more ethical use of lab. animals according to the 3R principles. In CMS, an exact vol. of the blood, plasma or other biofluid is collected in a capillary from which it is washed out, resulting in a dild. sample that can be handled using the existing equipment in the bioanal. lab. CMS differs from traditional large vol. sampling as the microsample is dild. before further handling and anal., and reanal. is performed using the dild. sample. This has some implications for the validation and this report is an attempt to clarify how to validate and use CMS methods in a regulatory environment. CMS also shows some distinct new opportunities: labile analytes can be immediately stabilized at sample collection and the addn. of the internal std. to the whole sample can improve anal. performance. The experiences from 5 years use of CMS of plasma and blood for detn. of drug exposure in animal studies are reviewed.

Place, publisher, year, edition, pages
2013. Vol. 5, no 6, 731-738 p.
National Category
Pharmaceutical Sciences Analytical Chemistry
URN: urn:nbn:se:uu:diva-197212DOI: 10.4155/bio.13.27ISI: 000318457500015OAI: oai:DiVA.org:uu-197212DiVA: diva2:611977

CAPLUS AN 2013:391975(Journal; Online Computer File)

Available from: 2013-03-19 Created: 2013-03-19 Last updated: 2013-06-10Bibliographically approved

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