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Characterization of enzyme sensitive responsive hydrogel/lipid system for triggered release
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Pharmacy, Department of Pharmacy.
2013 (English)Independent thesis Advanced level (degree of Master (Two Years)), 20 credits / 30 HE creditsStudent thesis
Abstract [en]

This master thesis aimed to create and characterize multilayer coatings upon mesoporous silica particles (MSP). The properties of the coating aimed for, was to have a triggerable controlled release, where a targeted enzyme within the intestine, alpha-amylase, is supposed to degrade the coating. The coating was created from a bilayer consisting of DOTAP and DOPC in a 1:3 molar ratio, which serves as a protective coating. The second layer interacting with the surroundings consisted of a starch component, amylopectin, which is degraded by alpha-amylase. The study of the coating was performed with ellipsometry, where the adsorption of the different layers of the coating on a planar silica surface and the enzyme-triggered degradation was recorded. The adsorbed amount of DOTAP/DOPC was 4,22 ± 0,11 mg/m2 and amylopectin 1,82 ± 0,94. The effects of different pH where performed, simulating the coated particle going through the gastro-intestinal system. Two enzymes alpha-amylase and phospholipase A2 (PLA2) where used for degradation of the coating. The knowledge from ellipsometry was applied to coating mesoporous silica particles and it was confirmed that the two layers had formed with zeta- potential measurement. 

Place, publisher, year, edition, pages
2013. , 54 p.
UPTEC K, ISSN 1650-8297 ; 13003
Keyword [en]
enzyme sensitive responsive hydrogel/lipid system for triggered release, liposomes, mesoporous silica, ellipsometry, coating
National Category
Other Chemical Engineering
URN: urn:nbn:se:uu:diva-197521OAI: oai:DiVA.org:uu-197521DiVA: diva2:613215
Educational program
Master Programme in Chemical Engineering
Available from: 2013-04-12 Created: 2013-03-26 Last updated: 2013-04-12Bibliographically approved

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Jónsson, Pétur
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