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The toxin-antitoxin system tisB-istR1 Expression, regulation and biological role in persister phenotypes
Uppsala University, Disciplinary Domain of Science and Technology, Biology, Department of Cell and Molecular Biology. Uppsala University, Science for Life Laboratory, SciLifeLab.
Uppsala University, Disciplinary Domain of Science and Technology, Biology, Department of Cell and Molecular Biology, Computational and Systems Biology. Uppsala University, Science for Life Laboratory, SciLifeLab.
2012 (English)In: RNA Biology, ISSN 1547-6286, E-ISSN 1555-8584, Vol. 9, no 12, 1513-1519 p.Article, review/survey (Refereed) Published
Abstract [en]

Chromosomally encoded toxin-antitoxin (TA) systems are abundantly present in bacteria and archaea. They have become a hot topic in recent years, because-after many frustrating years of searching for biological functions-some are now known to play roles in persister formation. Persisterscells represent a subset of a bacterial population that enters a dormant state and thus becomes refractory to the action of antibiotics. TA modules come in several different flavors, regarding the nature of their gene products, their molecular mechanisms of regulation, their cellular targets, and probably their role in physiology. This review will primarily focus on the SOS-associated tisB/istR1 system in Escherichia coli and discuss its nuts and bolts as well as its effect in promoting a subpopulation phenotype that likely benefits long-term survival of a stressed population.

Place, publisher, year, edition, pages
2012. Vol. 9, no 12, 1513-1519 p.
Keyword [en]
Toxin-antitoxin system, persisters, antisense RNA, sRNA, translational control
National Category
Medical and Health Sciences
Identifiers
URN: urn:nbn:se:uu:diva-197619DOI: 10.4161/rna.22578ISI: 000314451400016OAI: oai:DiVA.org:uu-197619DiVA: diva2:613737
Available from: 2013-04-01 Created: 2013-04-01 Last updated: 2017-12-06Bibliographically approved

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Wagner, Gerhart E. H.Unoson, Cecilia

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