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NF-kappa B activation by equine arteritis virus is MyD88 dependent and promotes viral replication
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Biochemistry and Microbiology.
2013 (English)In: Archives of Virology, ISSN 0304-8608, E-ISSN 1432-8798, Vol. 158, no 3, 701-705 p.Article in journal (Refereed) Published
Abstract [en]

NF-kappa B, a family of transcription factors involved in different cell functions and immune responses is targeted by viruses. The mechanism of NF-kappa B signalling and its role in replication of EAV have not been investigated. We demonstrate that EAV infection in BHK-21 cells activates NF-kappa B, and this activation was found to be mediated through the MyD88 pathway. Infection of IKK beta(-/-) murine embryo fibroblasts (MEFs), which are deficient in NF-kappa B signalling, resulted in lower virus titre, less cytopathic effect, and reduced expression of viral proteins. These findings implicate the MyD88 pathway in EAV-induced NF-kappa B activation and suggest that NF-kappa B activation is essential for efficient replication of EAV.

Place, publisher, year, edition, pages
2013. Vol. 158, no 3, 701-705 p.
National Category
Medical and Health Sciences
URN: urn:nbn:se:uu:diva-197630DOI: 10.1007/s00705-012-1515-4ISI: 000315561900021OAI: oai:DiVA.org:uu-197630DiVA: diva2:614004
Available from: 2013-04-03 Created: 2013-04-02 Last updated: 2014-11-17Bibliographically approved

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Paidikondala, Maruthibabu
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