NF-kappa B activation by equine arteritis virus is MyD88 dependent and promotes viral replication
2013 (English)In: Archives of Virology, ISSN 0304-8608, E-ISSN 1432-8798, Vol. 158, no 3, 701-705 p.Article in journal (Refereed) Published
NF-kappa B, a family of transcription factors involved in different cell functions and immune responses is targeted by viruses. The mechanism of NF-kappa B signalling and its role in replication of EAV have not been investigated. We demonstrate that EAV infection in BHK-21 cells activates NF-kappa B, and this activation was found to be mediated through the MyD88 pathway. Infection of IKK beta(-/-) murine embryo fibroblasts (MEFs), which are deficient in NF-kappa B signalling, resulted in lower virus titre, less cytopathic effect, and reduced expression of viral proteins. These findings implicate the MyD88 pathway in EAV-induced NF-kappa B activation and suggest that NF-kappa B activation is essential for efficient replication of EAV.
Place, publisher, year, edition, pages
2013. Vol. 158, no 3, 701-705 p.
Medical and Health Sciences
IdentifiersURN: urn:nbn:se:uu:diva-197630DOI: 10.1007/s00705-012-1515-4ISI: 000315561900021OAI: oai:DiVA.org:uu-197630DiVA: diva2:614004